CSF and blood oxytocin concentration changes following intranasal delivery in macaque

O Dal Monte, PL Noble, J Turchi, A Cummins… - PloS one, 2014 - journals.plos.org
Oxytocin (OT) in the central nervous system (CNS) influences social cognition and behavior,
making it a candidate for treating clinical disorders such as schizophrenia and autism …

Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques

SM Freeman, S Samineni, PC Allen… - …, 2016 - Elsevier
Oxytocin (OT) is a neuropeptide that mediates a variety of complex social behaviors in
animals and humans. Intranasal OT has been used as an experimental therapeutic for …

Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques

ME Modi, F Connor-Stroud, R Landgraf… - …, 2014 - Elsevier
Intranasal (IN) administration is a widely used method for examining the effect of oxytocin
(OT) on social behavior and cognition in healthy subjects and psychiatric populations. IN-OT …

Oxytocin delivered nasally or intraperitoneally reaches the brain and plasma of normal and oxytocin knockout mice

AS Smith, AC Korgan, WS Young - Pharmacological research, 2019 - Elsevier
Intranasal delivery of oxytocin (Oxt) has been identified as a potential therapeutic to target
human conditions characterized by social deficits, yet the ability of this administrative route …

Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans

N Striepens, KM Kendrick, V Hanking, R Landgraf… - Scientific reports, 2013 - nature.com
There has been an unprecedented interest in the modulatory effects of intranasal oxytocin
on human social cognition and behaviour, however as yet no study has actually …

Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay

MR Lee, KB Scheidweiler, XX Diao, F Akhlaghi… - Molecular …, 2018 - nature.com
Oxytocin (OT) is a potential treatment for multiple neuropsychiatric disorders. As OT is a
peptide, delivery by the intranasal (IN) route is the preferred method in clinical studies …

Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectives

DS Quintana, KT Smerud, OA Andreassen… - Therapeutic …, 2018 - Taylor & Francis
The neuropeptide oxytocin plays an evolutionarily conserved role in mammalian social
behavior. Despite striking effects on animal social behavior after intracerebroventricular drug …

Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study

K Daughters, ASR Manstead, K Hubble, A Rees… - PLOS …, 2015 - journals.plos.org
The use of intranasal oxytocin (OT) in research has become increasingly important over the
past decade. Although researchers have acknowledged a need for further investigation of …

Chronic and acute intranasal oxytocin produce divergent social effects in mice

H Huang, C Michetti, M Busnelli, F Manago… - …, 2014 - nature.com
Intranasal administration of oxytocin (OXT) might be a promising new adjunctive therapy for
mental disorders characterized by social behavioral alterations such as autism and …

Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

MR Lee, TA Shnitko, SW Blue, AV Kaucher… - Nature …, 2020 - nature.com
Oxytocin may have promise as a treatment for neuropsychiatric disorders. Its therapeutic
effect may depend on its ability to enter the brain and bind to the oxytocin receptor. To date …