Infection with Listeria monocytogenes can cause meningitis and septicemia in newborn,
elderly, or immunocompromised individuals. Pregnant women are particularly susceptible to …

The inflammasome pathway functions to regulate caspase‐1 activation in response to a
broad range of stimuli. Caspase‐1 activation is required for the maturation of the pivotal pro …

Listeria monocytogenes invades the cytoplasm of macrophages and induces the activation
of caspase-1 and the subsequent maturation of IL-1β and IL-18. Although apoptosis …

A host defense strategy against pathogens is the induction of cell death, thereby eliminating
the pathogen's intracellular niche. Pyroptosis, one such form of cell death, is dependent on …

Pathogens are detected by pattern recognition receptors that, upon activation, orchestrate
an appropriate immune response. The TLRs and the nucleotide-binding oligomerization …

Inflammasomes are intracellular multiprotein signaling complexes that activate Caspase-1,
leading to the cleavage and secretion of IL-1β and IL-18, and ultimately host cell death …

Inflammasomes are multimeric protein complexes that initiate inflammatory cascades. Their
activation is a hallmark of many infectious or inflammatory diseases. Their composition and …

Listeria monocytogenes escapes from the phagosome of macrophages and replicates within
the cytosolic compartment. The macrophage responds to L. monocytogenes through …

Different NOD-like receptors, including NLRP1, NLRP3, and NLRC4, as well as the recently
identified HIN-200 protein, AIM2, form multiprotein complexes called inflammasomes, which …

Caspase-1 activation is a key feature of the innate immune response of macrophages
elicited by pathogens and a variety of toxins. Here, we determined the requirement for …