Members of the polo subfamily of protein kinases have emerged as important regulators in
diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests …

Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-
like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region …

Abstract The Polo Kinase is a central regulator of cell division required for several events of
mitosis and cytokinesis. In addition to a kinase domain (KD), Polo-like kinases (Plks) …

Polo-like kinases (Plks) perform crucial functions in cell-cycle progression and multiple
stages of mitosis. Plks are characterized by a C-terminal noncatalytic region containing two …

Polo-like kinases (Plks) contain a conserved Polo-box domain, shown to bind to
phosphorylated Ser-pSer/pThr-Pro motifs. The Polo-box domain of Plk-1 mediates substrate …

Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

Mammalian polo-like kinases (Plks) are characterized by the presence of an N-terminal
protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate …

Polo-like kinase (Plk1) is crucial for cell cycle progression through mitosis. Here we present
the molecular and structural mechanisms that regulate the substrate recognition of Plk1 and …

Mammalian polo-like kinase 1 (Plk1) has been studied intensively as a key element in
regulating diverse mitotic events during M-phase progression. Plk1 is spatially regulated …

Abstract Polo-like kinase 1 (Plk1), the best characterized member of the mammalian polo-
like kinase family, is well regulated throughout the cell cycle at the protein expression level …