The inhibitory effect of supraphysiological iodide concentrations on thyroid hormone
synthesis (Wolff–Chaikoff effect) and on thyrocyte proliferation is largely known as iodine …

Although it is well known that an excess of iodide suppresses thyroid function and blood flow
in vivo, the underlying molecular mechanisms are not fully known. The functional effect of …

The thyroid gland is unique in its ability to respond to ambient levels of iodine to
autoregulate thyroid function and, possibly, thyroid cell proliferation. Although the inhibitory …

Iodine is an essential micronutrient for producing thyroid hormone (TH); however, iodide
excess can lead to adverse thyroidal effects. Unfortunately, the lack of a proper in vitro …

Background: The main molecular mechanism underlying acute suppression of iodine
organification in normal thyroids after an excessive iodine load, that is, the Wolff–Chaikoff …

Thyroid autonomy is a frequent cause of thyrotoxicosis in regions with iodine deficiency.
Epidemiological data suggest that iodide may influence the course of pre-existing thyroid …

Thyrotropin (TSH) regulates a number of genes in thyrocytes, leading to iodide uptake, de
novo synthesis and release of thyroid hormones, and cell proliferation, accompanied by …

Background: Iodine is essential for thyroid hormone synthesis and is an important regulator
of thyroid function. Chronic iodine deficiency leads to hypothyroidism, but iodine excess also …

Background: It is well known that iodide exacerbates thyroid function in subclinical
hypothyroid patients with autoimmune thyroiditis. To investigate the immunological …

Thyroid function ultimately depends on appropriate iodine supply to the gland. There is a
complex series of checks and balances that the thyroid uses to control the orderly utilization …