Gastric cancer (GC) is a common tumor‐associated lethal disease, and invasiveness and
metastasis are primary challenges in its clinical treatment. Hypoxia microenvironment …

AIM To investigate the relationship between hypoxia-inducible factor-1α (HIF-1α), prolyl 4-
hydroxylase beta (P4HB) expression, and clinicopathologic parameters, as well as the …

Hypoxia is a common feature of solid tumors including stomach cancer (SC) and is closely
associated with cancer malignant progression. N6-methyladenosine (m6A), a common …

Tissue hypoxia induces reprogramming of cell metabolism and may result in normal cell
transformation and cancer progression. Hypoxia-inducible factor 1-alpha (HIF-1α), the key …

Hypoxia-inducible factor-1 (HIF-1) is a major determinant of invasion and metastasis in
several tumor types. We previously reported that HIF-1α contributed to multidrug resistance …

The present study aimed to examine the association between hypoxia-inducible factor (HIF)-
1α and the Wnt/β-catenin signaling pathway in a hypoxic environment. The study also aimed …

In view of the high incidence of gastric cancer and the functions of hypoxia-inducible factor
1α (HIF-1α), our study aimed to investigate the functionality of HIF-1α in gastric cancer, and …

Abstract HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several
cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic …

Background: In microenvironment of malignant tumors, Hypoxia-Inducible Factors (HIF),
most importantly HIF-1α, play an important role in regulation of adaptive biological response …

Background The transcriptional factor hypoxia-inducible factor 1α (HIF-1α) controls
angiogenesis and metabolism by upregulating hypoxia-induced genes, such as the vascular …