Immunostimulatory properties of lipid modified CpG oligonucleotides
Innate immune responses recognizing pathogen associated molecular patterns play
important roles in adaptive immunity. As such, ligands which mimic the conserved products …
important roles in adaptive immunity. As such, ligands which mimic the conserved products …
Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy
KD Wilson, SD de Jong, YK Tam - Advanced drug delivery reviews, 2009 - Elsevier
There has been significant interest in the potential of cytosine–guanine (CpG) containing
oligodeoxynucleotides (ODN) as an immunotherapy for malignant, infectious and allergic …
oligodeoxynucleotides (ODN) as an immunotherapy for malignant, infectious and allergic …
CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
DM Klinman, S Klaschik, T Sato, D Tross - Advanced drug delivery reviews, 2009 - Elsevier
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune
adjuvants, accelerating and boosting antigen-specific immune responses. CpG motifs …
adjuvants, accelerating and boosting antigen-specific immune responses. CpG motifs …
Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides
Synthetic oligodeoxynucleotides (ODN) containing CpG sequences are recognized as a
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …
[HTML][HTML] Cooperation of oligodeoxynucleotides and synthetic molecules as enhanced immune modulators
S Nigar, T Shimosato - Frontiers in Nutrition, 2019 - frontiersin.org
Unmethylated cytosine–guanine dinucleotide (CpG) motifs are potent stimulators of the host
immune response. Cellular recognition of CpG motifs occurs via Toll-like receptor 9 (TLR9) …
immune response. Cellular recognition of CpG motifs occurs via Toll-like receptor 9 (TLR9) …
CpG DNA as a vaccine adjuvant
C Bode, G Zhao, F Steinhagen, T Kinjo… - Expert review of …, 2011 - Taylor & Francis
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells
that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) …
that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) …
Adjuvant activity of CpG oligodeoxynucleotides
DM Klinman - International reviews of immunology, 2006 - Taylor & Francis
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
Three CpG oligodeoxynucleotide classes differentially enhance antigen-specific humoral and cellular immune responses in mice
Y Liu, X Luo, C Yang, S Yu, H Xu - Vaccine, 2011 - Elsevier
Synthetic oligodeoxynucleotides containing unmethylated CpG-dinucleotides (CpG-ODNs)
are immunostimulatory in a broad spectrum of species. Extensive studies provide evidence …
are immunostimulatory in a broad spectrum of species. Extensive studies provide evidence …
Innovative strategies for co-delivering antigens and CpG oligonucleotides
Y Krishnamachari, AK Salem - Advanced drug delivery reviews, 2009 - Elsevier
Cytosine–phosphorothioate–guanine oligodeoxynucleotides (CpG ODN) is a recent class of
immunostimulatory adjuvants that includes unmethylated CpG dinucleotide sequences …
immunostimulatory adjuvants that includes unmethylated CpG dinucleotide sequences …
CpG DNA as a vaccine adjuvant
DM Klinman - Expert review of vaccines, 2003 - Taylor & Francis
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs act as immune
adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold …
adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold …