Prophylactic vaccines mimic synthetic CpG oligonucleotides in their ability to modulate immune responses
IJM de Vries, J Tel, D Benitez-Ribas, R Torensma… - Molecular …, 2011 - Elsevier
Synthetic oligonucleotide ligands that bind to toll-like receptors are known to modulate the
immune response via the activation of antigen presenting cells, and were therefore …
immune response via the activation of antigen presenting cells, and were therefore …
Effects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentials
CpG oligodeoxynucleotides (ODNs) are promising immunomodulatory agents for treating
human diseases and vaccine development. Phosphodiester CpG ODNs were demonstrated …
human diseases and vaccine development. Phosphodiester CpG ODNs were demonstrated …
Conjugation of lipid and CpG-containing oligonucleotide yields an efficient method for liposome incorporation
CD Andrews, CJ Provoda, G Ott, KD Lee - Bioconjugate chemistry, 2011 - ACS Publications
For optimal stimulation of T cells, protein-based vaccines must deliver protein antigens to
antigen-presenting cells while simultaneously providing immunostimulatory signals …
antigen-presenting cells while simultaneously providing immunostimulatory signals …
Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides.
Bacterial DNA contains immunostimulatory CpG motifs that interact with toll-like receptor 9
on immune cells to stimulate the production of cytokines, chemokines and immunoglobulins …
on immune cells to stimulate the production of cytokines, chemokines and immunoglobulins …
Therapeutic applications of synthetic CpG oligodeoxynucleotides as TLR9 agonists for immune modulation
M Jurk, J Vollmer - BioDrugs, 2007 - Springer
Vertebrate toll-like receptors (TLRs) sense invading pathogens by recognizing bacterial and
viral structures and, as a result, activate innate and adaptive immune responses. Ten human …
viral structures and, as a result, activate innate and adaptive immune responses. Ten human …
CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+ CD11c+ monocytes
T Sugiyama, M Gursel, F Takeshita… - The Journal of …, 2005 - journals.aai.org
Synthetic immunostimulatory nucleic acids such as CpG DNA are being harnessed
therapeutically as vaccine adjuvants, anticancer or antiallergic agents. Efforts to identify …
therapeutically as vaccine adjuvants, anticancer or antiallergic agents. Efforts to identify …
Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9
D Yu, D Wang, FG Zhu, L Bhagat, M Dai… - Journal of medicinal …, 2009 - ACS Publications
Oligodeoxynucleotides (ODNs) containing unmethylated CpG dinucleotides act as agonists
of TLR9 and induce Th1-type immune responses. In the present study, we synthesized CpG …
of TLR9 and induce Th1-type immune responses. In the present study, we synthesized CpG …
Highly immunostimulatory CpG-free oligodeoxynucleotides for activation of human leukocytes
J Vollmer, A Janosch, M Laucht, ZK Ballas… - … and Nucleic Acid …, 2002 - liebertpub.com
Synthetic oligodeoxynucleotides (ODNs) bearing CpG dinucleotides can mimic the
immunostimulatory effects of bacterial DNA in vertebrates. Besides the known CpG motifs …
immunostimulatory effects of bacterial DNA in vertebrates. Besides the known CpG motifs …
A novel class of immune-stimulatory CpG oligodeoxynucleotides unifies high potency in type I interferon induction with preferred structural properties
U Samulowitz, M Weber, R Weeratna, E Uhlmann… - …, 2010 - liebertpub.com
Unmethylated deoxycytidyl-deoxyguanosin dinucleotide (CpG)-containing
oligodeoxynucleotides (ODNs) have been well characterized as agonists for Toll-like …
oligodeoxynucleotides (ODNs) have been well characterized as agonists for Toll-like …
Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
Oligodeoxynucleotides (ODN) that contain unmethylated CpG dinucleotides trigger a strong
innate immune response in vertebrates. CpG ODN show promise as vaccine adjuvants, anti …
innate immune response in vertebrates. CpG ODN show promise as vaccine adjuvants, anti …