Glioblastoma multiforme (GBM) is the most commonly occurring brain cancer, and is
characterized by its poor patient outcomes. The present study examined the mRNA …

Background Glioblastoma multiforme (GBM) is the most common and aggressive primary
brain tumor with a dismal prognosis. Despite intensive study on tumor biology, the …

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed ion channel with intrinsic kinase activity. Molecular and electrophysiological …

The goal of this article is to provide a critical review of the transient receptor potential
melastatin-subfamily member 8 (TRPM8) in cancers, with an emphasis on its roles in cellular …

TRPM7 is a non-selective divalent cation channel with an alpha-kinase domain.
Corresponding with its broad expression, TRPM7 has a role in a wide range of cell …

Glioblastomas are progressive brain tumors with devastating proliferative and invasive
characteristics. Ion channels are the second largest target class for drug development. In this …

Cancer is a multifactorial process associated with changes in signaling pathways leading to
cell cycle variations and gene expression. The transient receptor potential melastatin 8 …

Ion channels are ubiquitously expressed in almost all living cells, and are the third-largest
category of drug targets, following enzymes and receptors. The transient receptor potential …

Gliomas are the most common type of primary brain tumor. Despite advances in treatment, it
remains one of the most aggressive and deadly tumor of the central nervous system (CNS) …

Abstract TRPM8 is a Ca 2+-permeable nonselective cation channel belonging to the
melastatin sub-group of the transient receptor potential (TRP) family. TRPM8 is aberrantly …