The phenoxyacetyl (Pac) group proved to be useful for the synthesis of
oligodeoxyribonucleotides incorporating a 6-O-ethylguanine. Since the Pac group could be …

Abstract N 6'N 6, 3′, 5′-O-Protected deoxyadenosine derivatives were found to be key
intermediate for synthesis of oligodeoxyribonucleotides. Treatment of protected …

Methoxybenzyl group was introduced directly to the 2′-hydroxyl group from the reaction of
adenosine with 4-methoxybenzyl bromide in the presence of sodium hydride. The 2′-O-(4 …

Abstract The 3, 4-dimethoxybenzyl group was introduced to the 2′-hydroxyl group by the
reaction of nucleosides with 3, 4-dimethoxybenzyl trichloroacetimidate or 3, 4 …

A phthaloyl group has been introduced into the N 6-amino group of deoxyadenosine via
silylation followed by acylation. The phthaloyl group resulted in remarkable retarding effects …

The protection of the 06—amide group of deoxyguanosine with the 3, 4—methoxybenzyl
group is described. This protecting group could be intro—duced effectively and was readily …

Methoxy-4-phenoxybenzoyl group has been used for the protection of exocyclic amino
group of nucleosides. In case of 2′-deoxycytidine it has been found to be highly selective …

We developed a new convenient method for generation of an abasic site at the 3 '-terminus
of an oligonucleotide. This method uses a 1-deaza-2 '-deoxyguanosine residue, which …

The protection of the 6-oxo group of deoxyguanosine with the 2-trimethylsilylethyl (2),
phenylthioethyl (3), 4-nitrophenylthioethyl (4), 4-nintrophenethyl (5), and cyanoethyl (6) …

Isopropoxyacetic anhydride was successfully used for protection of exoaminofunctions of
2′-deoxyadenosine,–guanosine and-cytidine. N-isopropoxyacetylated nucleosides are …