Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer and the third
leading cause of cancer death in both sexes in the United States. 1 However, in Central and …

See “Proximal and large hyperplastic and nondysplastic serrated polyps detected by
colonoscopy are associated with neoplasia,” Schreiner MA, Weiss DG, Lieberman DA, et al …

A strong evidence base supports colorectal cancer screening. Interruption of the adenoma-
carcinoma sequence by endoscopic polypectomy has been considered the key step in …

In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

Until 20 years ago, 2 major forms of colorectal epithelial polyp were recognized: the
adenoma and the hyperplastic polyp. Adenomas have long been accepted as neoplastic …

Although hyperplastic polyps (HPs) were once believed to have a benign course with little
clinical significance, they are now recognized as part of a broader group of lesions known as …

Serrated adenoma (SA), firstly described in 1990 represent about 9% of the resected polyps
during colonoscopy.[1] For a long time, SA and hyperplastics polyps (HP) were not …

OBJECTIVES: Serrated polyps are precursors in an alternative pathway to colon cancer.
These polyps are frequently sessile or flat, located in the proximal colon, and may be …

Background Although serrated polyposis syndrome (SPS) is associated with an increased
colorectal cancer (CRC) risk, the carcinogenic mechanisms remain unknown. We …

Identification of the serrated neoplasia pathway has improved our understanding of the
pathogenesis of colorectal cancer (CRC). Insights include an increased recognition of the …