This study investigated the functional significance of hyperalgesia in the CCL2/CCR2
signaling system in trigeminal ganglion (TG) neurons following inflammation. Inflammation …

Glial cells activated by peripheral nerve injury contribute to the induction and maintenance
of neuropathic pain by releasing neuromodulating cytokines and chemokines. We …

Background Chemokine-mediated neuroinflammation plays an important role in the
pathogenesis of neuropathic pain. The chemokine CC motif ligand 7 (CCL7) and its receptor …

Background Neuropathic pain in the trigeminal system is frequently observed in clinic, but
the mechanisms involved are largely unknown. In addition, the function of immune cells and …

Purpose Trigeminal neuropathic pain is very common clinically, but effective treatments are
lacking. Chemokines and their receptors have been implicated in the pathogenesis of …

The CXCR2 chemokine receptor is known to have a significant impact on the initiation and
control of inflammatory processes. However, its specific involvement in the sensation of itch …

Abstract Background Chemokine (C‐C motif) ligand 2 (CCL2) participates in different
mechanisms contributing to the spinal cord inflammation and pain development after sciatic …

Recent findings demonstrate that chemokines, and more specifically CC chemokine ligand 2
(CCL2 or monocyte chemoattractant protein-1), play a major role in pain processing. In the …

Objective Despite accumulating evidence on a role of immune cells and their associated
chemicals in mechanisms of pain, few studies have addressed the potential role of …

CXCL1 and CXCL2 are two chemokines with 78% homology of their sequence. CXCL1 was
associated with atopic dermatitis, a highly pruritic skin disease, but it is not clear what is its …