Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice

JS Schor, AB Nelson - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
Deep brain stimulation (DBS) is used to treat multiple neuropsychiatric disorders, including
Parkinson's disease (PD). Despite widespread clinical use, its therapeutic mechanisms are …

Deep brain stimulation for psychiatric disease: contributions and validity of animal models

C Hamani, Y Temel - Science translational medicine, 2012 - science.org
During treatment with deep brain stimulation (DBS), electrical current is delivered into the
brain parenchyma through implanted electrodes. Although this technique is routinely used in …

Subthalamic nucleus deep brain stimulation driven by primary motor cortex γ2 activity in parkinsonian monkeys

O Darbin, N Hatanaka, S Takara, N Kaneko… - Scientific Reports, 2022 - nature.com
In parkinsonism, subthalamic nucleus (STN) electrical deep brain stimulation (DBS)
improves symptoms, but may be associated with side effects. Adaptive DBS (aDBS), which …

Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats

CS Oza, DT Brocker, CE Behrend… - Journal of …, 2018 - journals.physiology.org
Deep brain stimulation (DBS) is an effective therapy for movement disorders, including
Parkinson's disease (PD), although the mechanisms of action remain unclear. Abnormal …

Evolution of deep brain stimulation: human electrometer and smart devices supporting the next generation of therapy

KH Lee, CD Blaha, PA Garris, P Mohseni… - … : Technology at the …, 2009 - Elsevier
Deep brain stimulation (DBS) provides therapeutic benefit for several neuropathologies,
including Parkinson disease (PD), epilepsy, chronic pain, and depression. Despite well …

Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation

GC McConnell, RQ So, WM Grill - Journal of …, 2016 - journals.physiology.org
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established treatment for the
motor symptoms of Parkinson's disease (PD). However, the mechanisms of action of DBS …

Closed-loop deep brain stimulation effects on parkinsonian motor symptoms in a non-human primate–is beta enough?

LA Johnson, SD Nebeck, A Muralidharan, MD Johnson… - Brain stimulation, 2016 - Elsevier
Background Incorporating feedback controls based on real-time measures of pathological
brain activity may improve deep brain stimulation (DBS) approaches for the treatment of …

Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice

JS Schor, IG Montalvo, PWE Spratt, RJ Brakaj… - Elife, 2022 - elifesciences.org
Subthalamic nucleus deep brain stimulation (STN DBS) relieves many motor symptoms of
Parkinson's disease (PD), but its underlying therapeutic mechanisms remain unclear. Since …

Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns

GC McConnell, RQ So, JD Hilliard… - Journal of …, 2012 - Soc Neuroscience
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for
the motor symptoms of Parkinson's disease (PD). The effects of DBS depend strongly on …

Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities

LHN Lee, CS Huang, RW Wang, HJ Lai… - npj Parkinson's …, 2022 - nature.com
The success of deep brain stimulation (DBS) therapy indicates that Parkinson's disease is a
brain rhythm disorder. However, the manifestations of the erroneous rhythms corrected by …