Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice
Deep brain stimulation (DBS) is used to treat multiple neuropsychiatric disorders, including
Parkinson's disease (PD). Despite widespread clinical use, its therapeutic mechanisms are …
Parkinson's disease (PD). Despite widespread clinical use, its therapeutic mechanisms are …
Deep brain stimulation for psychiatric disease: contributions and validity of animal models
During treatment with deep brain stimulation (DBS), electrical current is delivered into the
brain parenchyma through implanted electrodes. Although this technique is routinely used in …
brain parenchyma through implanted electrodes. Although this technique is routinely used in …
Subthalamic nucleus deep brain stimulation driven by primary motor cortex γ2 activity in parkinsonian monkeys
O Darbin, N Hatanaka, S Takara, N Kaneko… - Scientific Reports, 2022 - nature.com
In parkinsonism, subthalamic nucleus (STN) electrical deep brain stimulation (DBS)
improves symptoms, but may be associated with side effects. Adaptive DBS (aDBS), which …
improves symptoms, but may be associated with side effects. Adaptive DBS (aDBS), which …
Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats
CS Oza, DT Brocker, CE Behrend… - Journal of …, 2018 - journals.physiology.org
Deep brain stimulation (DBS) is an effective therapy for movement disorders, including
Parkinson's disease (PD), although the mechanisms of action remain unclear. Abnormal …
Parkinson's disease (PD), although the mechanisms of action remain unclear. Abnormal …
Evolution of deep brain stimulation: human electrometer and smart devices supporting the next generation of therapy
Deep brain stimulation (DBS) provides therapeutic benefit for several neuropathologies,
including Parkinson disease (PD), epilepsy, chronic pain, and depression. Despite well …
including Parkinson disease (PD), epilepsy, chronic pain, and depression. Despite well …
Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established treatment for the
motor symptoms of Parkinson's disease (PD). However, the mechanisms of action of DBS …
motor symptoms of Parkinson's disease (PD). However, the mechanisms of action of DBS …
Closed-loop deep brain stimulation effects on parkinsonian motor symptoms in a non-human primate–is beta enough?
Background Incorporating feedback controls based on real-time measures of pathological
brain activity may improve deep brain stimulation (DBS) approaches for the treatment of …
brain activity may improve deep brain stimulation (DBS) approaches for the treatment of …
Therapeutic deep brain stimulation disrupts movement-related subthalamic nucleus activity in parkinsonian mice
JS Schor, IG Montalvo, PWE Spratt, RJ Brakaj… - Elife, 2022 - elifesciences.org
Subthalamic nucleus deep brain stimulation (STN DBS) relieves many motor symptoms of
Parkinson's disease (PD), but its underlying therapeutic mechanisms remain unclear. Since …
Parkinson's disease (PD), but its underlying therapeutic mechanisms remain unclear. Since …
Effective deep brain stimulation suppresses low-frequency network oscillations in the basal ganglia by regularizing neural firing patterns
GC McConnell, RQ So, JD Hilliard… - Journal of …, 2012 - Soc Neuroscience
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for
the motor symptoms of Parkinson's disease (PD). The effects of DBS depend strongly on …
the motor symptoms of Parkinson's disease (PD). The effects of DBS depend strongly on …
Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities
LHN Lee, CS Huang, RW Wang, HJ Lai… - npj Parkinson's …, 2022 - nature.com
The success of deep brain stimulation (DBS) therapy indicates that Parkinson's disease is a
brain rhythm disorder. However, the manifestations of the erroneous rhythms corrected by …
brain rhythm disorder. However, the manifestations of the erroneous rhythms corrected by …
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