Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling

RD Guzy, L Li, C Smith, SJ Dorry, HY Koo… - Journal of Biological …, 2017 - ASBMB
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive pulmonary scarring,
decline in lung function, and often results in death within 3–5 five years after diagnosis …

Fibroblast growth factor‐1 attenuates TGF‐β1‐induced lung fibrosis

C Shimbori, PS Bellaye, J Xia, J Gauldie… - The Journal of …, 2016 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive fibroblast and
myofibroblast proliferation, and extensive deposition of extracellular matrix (ECM). Fibroblast …

Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin

RD Guzy, I Stoilov, TJ Elton, RP Mecham… - American journal of …, 2015 - atsjournals.org
The pathogenesis of pulmonary fibrosis involves lung epithelial injury and aberrant
proliferation of fibroblasts, and results in progressive pulmonary scarring and declining lung …

Fibroblast growth factor 2 decreases bleomycin‐induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation

HY Koo, LMF El‐Baz, SL House… - The Journal of …, 2018 - Wiley Online Library
Fibroblast growth factor (FGF) signaling has been implicated in the pathogenesis of
pulmonary fibrosis. Mice lacking FGF2 have increased mortality and impaired epithelial …

FGF9 and FGF18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts in vitro

A Joannes, S Brayer, V Besnard… - … of Physiology-Lung …, 2016 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is characterized by an accumulation of extracellular
matrix proteins and fibroblasts in the distal airways. Key developmental lung signaling …

Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis

BA MacKenzie, M Korfei, I Henneke, Z Sibinska… - Respiratory …, 2015 - Springer
Background Recent clinical studies show that tyrosine kinase inhibitors slow the rate of lung
function decline and decrease the number of acute exacerbations in patients with Idiopathic …

FGF-1 reverts epithelial-mesenchymal transition induced by TGF-β1 through MAPK/ERK kinase pathway

C Ramos, C Becerril, M Montaño… - … of Physiology-Lung …, 2010 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by
the expansion of the fibroblast/myofibroblast population and aberrant remodeling. However …

Signaling pathways in the epithelial origins of pulmonary fibrosis

WD Hardie, JS Hagood, V Dave, AKT Perl, AKT Perl… - Cell Cycle, 2010 - Taylor & Francis
Pulmonary fibrosis complicates a number of disease processes and leads to substantial
morbidity and mortality. Idiopathic pulmonary fibrosis (IPF) is perhaps the most pernicious …

Bleomycin-enhanced alternative splicing of fibroblast growth factor receptor 2 induces epithelial to mesenchymal transition in lung fibrosis

KJ Chen, Q Li, CM Weng, ZX Duan… - Bioscience …, 2018 - portlandpress.com
Idiopathic pulmonary fibrosis (IPF) is an important public health problem, and it has few
treatment options given its poorly understood etiology; however, epithelial to mesenchymal …

Prostaglandin F receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β

T Oga, T Matsuoka, C Yao, K Nonomura, S Kitaoka… - Nature medicine, 2009 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by fibroblast
proliferation and excess deposition of collagen and other extracellular matrix (ECM) …