Serotonin selectively modulates reward value in human decision-making

B Seymour, ND Daw, JP Roiser, P Dayan… - Journal of …, 2012 - Soc Neuroscience
Establishing a function for the neuromodulator serotonin in human decision-making has
proved remarkably difficult because if its complex role in reward and punishment …

Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues

RD Rogers, EM Tunbridge, Z Bhagwagar… - …, 2003 - nature.com
While accumulating evidence suggests that effective real-life decision-making depends
upon the functioning of the orbitofrontal cortex, much less is known about the involvement of …

Serotonin shapes risky decision making in monkeys

AB Long, CM Kuhn, ML Platt - Social cognitive and affective …, 2009 - academic.oup.com
Some people love taking risks, while others avoid gambles at all costs. The neural
mechanisms underlying individual variation in preference for risky or certain outcomes …

Serotonin affects association of aversive outcomes to past actions

SC Tanaka, K Shishida, N Schweighofer… - Journal of …, 2009 - Soc Neuroscience
Impairment in the serotonergic system has been linked to action choices that are less
advantageous in a long run. Such impulsive choices can be caused by a deficit in linking a …

Serotonin and the evaluation of future rewards: theory, experiments, and possible neural mechanisms

N Schweighofer, SC Tanaka… - Annals of the New York …, 2007 - Wiley Online Library
The ability to select an action by considering both delays and amount of reward outcome is
critical for survival and well‐being of animals and humans. Previous animal experiments …

Reconciling the role of serotonin in behavioral inhibition and aversion: acute tryptophan depletion abolishes punishment-induced inhibition in humans

MJ Crockett, L Clark, TW Robbins - Journal of Neuroscience, 2009 - Soc Neuroscience
The neuromodulator serotonin has been implicated in a large number of affective and
executive functions, but its precise contribution to motivation remains unclear. One influential …

Low-serotonin levels increase delayed reward discounting in humans

N Schweighofer, M Bertin, K Shishida… - Journal of …, 2008 - Soc Neuroscience
Previous animal experiments have shown that serotonin is involved in the control of
impulsive choice, as characterized by high preference for small immediate rewards over …

The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans

RD Rogers - Neuropsychopharmacology, 2011 - nature.com
Neurophysiological experiments in primates, alongside neuropsychological and functional
magnetic resonance investigations in humans, have significantly enhanced our …

Beyond negative valence: 2-week administration of a serotonergic antidepressant enhances both reward and effort learning signals

J Scholl, N Kolling, N Nelissen, M Browning… - PLoS …, 2017 - journals.plos.org
To make good decisions, humans need to learn about and integrate different sources of
appetitive and aversive information. While serotonin has been linked to value-based …

The role of serotonin in nonnormative risky choice: the effects of tryptophan supplements on the “reflection effect” in healthy adult volunteers

SE Murphy, C Longhitano, RE Ayres… - Journal of Cognitive …, 2009 - direct.mit.edu
Risky decision-making involves weighing good and bad outcomes against their probabilities
in order to determine the relative values of candidate actions. Although human decision …