Purpose Panel testing has led to the identification of TP53 pathogenic/likely pathogenic
(P/LP) variant carriers (TP53+) who exhibit a broad range of phenotypes. We sought to …

Pathogenic germline variants in the TP53 gene predispose to a wide range of cancers,
known collectively as Li-Fraumeni syndrome (LFS). There has been much research aimed to …

PURPOSE Multigene panel testing (MGPT) identifies TP53 pathogenic or likely pathogenic
(P/LP) variants in patients with diverse phenotypes, of which only one is classic Li-Fraumeni …

TP53 pathogenic germline variation is associated with the multi-cancer predisposition Li–
Fraumeni syndrome (LFS). Next-generation sequencing and multigene panel testing are …

Li–Fraumeni syndrome (LFS) is an autosomal‐dominant cancer predisposition disorder
associated with pathogenic germline variants in TP53, with a high penetrance over an …

Pathogenic or likely pathogenic (P/LP) germline TP53 variants are the primary cause of Li-
Fraumeni syndrome (LFS), a hereditary cancer predisposition disorder characterized by …

Summary Background Li-Fraumeni syndrome, caused primarily by pathogenic or likely
pathogenic germline TP53 variants, is a rare, variably penetrant, cancer predisposition …

Importance Li-Fraumeni syndrome is a cancer predisposition syndrome that is associated
with a high, lifelong risk of a broad spectrum of cancers that is caused by …

PURPOSE Establishing accurate age-related penetrance figures for the broad range of
cancer types that occur in individuals harboring a pathogenic germline variant in the TP53 …

Previous analysis of next‐generation sequencing (NGS) hereditary pan‐cancer panel
testing demonstrated that approximately 40% of TP53 pathogenic and likely pathogenic …