Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF‐β as major players and therapeutic targets

AM Gressner, R Weiskirchen - Journal of cellular and molecular …, 2006 - Wiley Online Library
Hepatic fibrosis is a scarring process that is associated with an increased and altered
deposition of extracellular matrix in liver. At the cellular and molecular level, this progressive …

Hepatic fibrosis

J Jiao, SL Friedman, C Aloman - Current opinion in …, 2009 - journals.lww.com
Hepatic fibrosis : Current Opinion in Gastroenterology Hepatic fibrosis : Current Opinion in
Gastroenterology Log in or Register Subscribe to journalSubscribe Get new issue alertsGet …

[PDF][PDF] Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell

E Gabele, DA Brenner, RA Rippe - Front Biosci, 2003 - article.imrpress.com
[Frontiers in Bioscience 8, d69-77, January 1, 2003] 69 LIVER FIBROSIS: SIGNALS LEADING
TO THE AMPLIFICATION OF THE FIBROGENIC H Page 1 [Frontiers in Bioscience 8, d69-77 …

Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis

T Kisseleva, DA Brenner - Journal of gastroenterology and …, 2007 - Wiley Online Library
Liver fibrosis is caused by many chronic diseases. Liver injury results in activation of
collagen‐producing cells and excessive deposition of extracellular matrix proteins. This …

Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy

D Li, S Friedman - Journal of gastroenterology and hepatology, 1999 - Wiley Online Library
Hepatic fibrosis is a wound‐healing response to chronic liver injury, which if persistent leads
to cirrhosis and liver failure. Exciting progress has been made in understanding the …

[HTML][HTML] Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update

GÖ Elpek - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Hepatic fibrosis, stellate cells, and portal hypertension

DC Rockey - Clinics in Liver Disease, 2006 - liver.theclinics.com
Background Hepatic fibrogenesis is the common result of injury to the liver. Further, fibrosis
is believed to be a critical factor that leads to hepatic dysfunction and may be important in …

Translating an understanding of the pathogenesis of hepatic fibrosis to novel therapies

DC Rockey - Clinical gastroenterology and hepatology, 2013 - Elsevier
The response to injury is one of wound healing and fibrogenesis, which ultimately leads to
fibrosis. The fibrogenic response to injury is a generalized one across virtually all organ …

Pathogenesis of liver fibrosis

V Hernandez-Gea, SL Friedman - Annual review of pathology …, 2011 - annualreviews.org
Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options

OA Gressner, R Weiskirchen, AM Gressner - Comparative hepatology, 2007 - Springer
Despite intensive studies, the clinical opportunities for patients with fibrosing liver diseases
have not improved. This will be changed by increasing knowledge of new pathogenetic …