RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying
these global interactions remain poorly understood. We elucidated regulatory mechanisms …

Gene expression in eukaryotes is subject to extensive regulation at posttranscriptional
levels. One of the most important sites of control involves mRNA 3′ untranslated regions …

Posttranscriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA …

The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs
encoding proteins with roles in cell division, cell survival, immune response, and …

The microRNA (miRNA)-mediated repression of protein synthesis in mammalian cells is a
reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3 …

HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that
acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA …

RNA-binding protein HuR modulates the stability and translational efficiency of messenger
RNAs (mRNAs) encoding essential components of the cellular proliferation, growth and …

During the last decade evidence from numerous studies has been accumulated
demonstrating that posttranscriptional gene regulation including mRNA turnover and …

MicroRNAs (miRNAs) and small interfering RNAs (siRNAs), bound to Argonaute proteins
(RISC), destabilize mRNAs through base-pairing with the mRNA. However, the gene …

The RNA-binding protein HuR regulates the stability and translation of target mRNAs. While
no HuR mutations have been found in cancer, a link between HuR and malignant …