INTRODUCTION MicroRNAs (miRNAs) are short RNAs that guide repression of mRNA
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …

There is a growing body of evidence about the presence and the activity of the miRISC in the
nucleus of mammalian cells. Here, we show by quantitative proteomic analysis that Ago2 …

MicroRNAs (miRNAs) are~ 21-nt-long RNAs involved in regulating development,
differentiation, and other processes in eukaryotes. In metazoa, nearly all miRNAs control …

RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of
RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes …

The RNA-binding protein HuD promotes neurogenesis and favors recovery from peripheral
axon injury. HuD interacts with many mRNAs, altering both stability and translation …

AU-rich elements (AREs) located in the 3′ UTRs of the messenger RNAs (mRNAs) of many
mammalian early response genes promote rapid mRNA turnover. HuR, an RRM-containing …

AU-rich elements (AREs) present in the 3′ untranslated regions of many protooncogene,
cytokine, and lymphokine messages target them for rapid degradation. HuR, a ubiquitously …

Approximately 3 000 genes are regulated in a time‐, tissue‐, and stimulus‐dependent
manner by degradation or stabilization of their mRNAs. The process is mediated by …

The RNA‐binding protein HuR regulates the stability and translation of numerous mRNAs
encoding stress‐response and proliferative proteins. Although its post‐transcriptional …

Abstract mRNA stability is increasingly recognized as being essential for controlling the
expression of a wide variety of transcripts during neuronal development and synaptic …