Background It is unclear whether decreased serotonin transporter function contributes to
sensorimotor abnormalities in irritable bowel syndrome. Aim To study the influence of acute …

Aims 5‐hydroxytryptamine3 receptor antagonists act antiemetically and slow colonic transit.
This study evaluated effects of the high‐affinity 5‐HT3 antagonist, cilansetron, on fasting …

The effects of central or peripheral administration of serotonin on colonic expulsion time
(CE) of a glass bead were evaluated after ip or free hand icv administration to mice …

Altered serotonin signaling has been implicated in the pathophysiology of irritable bowel
syndrome (IBS). Selective serotonin reuptake inhibitors (SSRI) improve IBS symptoms …

Background: Although antidepressants are used for functional gastrointestinal disorders, the
mechanisms of their effects on gut are incompletely understood. Aim: To assess the effects …

Aliment Pharmacol Ther 2010; 32: 289–295 Summary Background Administration of 5‐
hydroxytryptamine (5HT) and selective 5HT receptor ligands modifies interdigestive motility …

Serotonin‐selective reuptake transporter (SERT) expression is decreased in animal models
of intestinal inflammation and in individuals with inflammatory bowel disease (IBD) or …

Background: Serotonin (5-HT) may play an important role in the regulation of colonic motility
in humans. However, it is not known whether alterations in the colonic 5-HT system are …

Colonic motor function is modulated by extended and local neural reflexes involving
unknown mediators. To test the role of serotonin (5-HT3) pathways, increases in colonic …

The role of serotonin (5‐hydroxytryptamine [5‐HT]) in gastrointestinal motility has been
studied for over 50 years. Most of the 5‐HT in the body resides in the gut wall, where it is …