Tertiary alcohols are widely represented in nature and among bioactive molecules. Their
importance is attested by the continuous efforts to meet the challenge of their stereoselective …

Aldolases are key biocatalysts for stereoselective C–C bond formation allowing access to
polyoxygenated chiral units through direct, efficient, and sustainable synthetic processes …

Pyruvate aldolases from Pfam family PF03328, recently described to be able to use
hydroxypyruvic acid as nucleophile substrate, were shown to also catalyse aldol adducts …

Originally named according to their strict nucleophile specificity towards pyruvate, some
pyruvate aldolases were demonstrated to be able to convert other nucleophiles. This study …

Amino acids are of paramount importance as chiral building blocks of life, for drug
development in modern medicinal chemistry, and for the manufacture of industrial products …

Hydroxy‐2‐keto acid derivatives are versatile building blocks for the synthesis of amino
acids, hydroxy carboxylic acids and chiral aldehydes. Pyruvate aldolases are privileged …

d-Fructose 6-phosphate aldolase (FSA) catalyzes the asymmetric cross-aldol addition of
phenylacetaldehyde and hydroxyacetone. We conducted structure-guided saturation …

Aldolases are powerful C–C bond-forming enzymes in biocatalysis because of their
unparalleled stereoselectivity, the ease with which reactions that do not require cofactor …

Chiral 2-hydroxy acids and 2-hydroxy-4-butyrolactone derivatives are structural motifs often
found in fine and commodity chemicals. Here, we report a tandem biocatalytic …

Polystyrene‐supported (PS) diarylprolinol catalysts 1 a (Ar= phenyl) and 1 b (Ar= 3, 5‐bis
(trifluoromethyl) phenyl) have been developed. Operating under site‐isolation conditions …