Rationale Tobacco smoke contains nicotine and many other compounds that act in concert
on the brain reward system. Therefore, animal models are needed that allow the …

Metabolism of nicotine to inactive cotinine by hepatic enzyme CYP2A6 is the principal
pathway by which active nicotine is removed from circulation. We therefore hypothesized …

Rationale Epidemiological studies have demonstrated a comorbidity of smoking with
depression and anxiety, particularly during adolescence. However, few animal studies have …

Background Previous research has shown that smokers have reduced brain and platelet
monoamine oxidase B (MAOB) activity. This is probably due to some components of tobacco …

The inhibition of cerebral monoamine oxidases (MAOs) by cigarette smoke components
could participate to the tobacco addiction. However, the actual extent of this inhibition in vivo …

This study was designed to demonstrate that dopaminergic stimulation would result in
decreased smoking behavior and nicotine intake, whereas dopaminergic blockade would …

Several minor tobacco alkaloids have been found to exhibit properties pharmacologically
relevant to the addictive profile of tobacco; however, little is known of their effects on a …

In rats, a distinct environment repeatedly paired with nicotine (0.421 mg/kg base, sc) comes
to evoke an increase in activity in the absence of any drug. This hyperactivity indicates a …

Studies have demonstrated that smokers have lower levels of brain monoamine oxidase
(MAO) A and B activity and lower MAO-B platelet activity than non-smokers. Recent …

Current understanding of the mechanisms through which nicotine acts to reinforce behavior
is limited. Demonstrated interactions between nicotine and the mesolimbic dopamine …