the islet contains a dense vascular structure of several features. the expression of vascular
endothelial growth factor (VEGF)-A in beta cells is indispensable for the formation of this …

Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …

Blood vessel endothelium has been recently shown to induce endocrine pancreatic
development [1]. Because pancreatic endocrine cells or islets express high levels of …

Mice, deficient for vascular endothelial growth factor VEGF-A in pancreatic islets, have
reduced insulin gene expression levels and an impaired glucose tolerance. Here, we …

The inability to increase of islet mass adequately to compensate for the demand of insulin
due to insulin resistance is an important pathophysiological feature of type 2 diabetes …

VEGF-A expression in beta cells is critical for pancreatic development, formation of islet-
specific vasculature, and Insulin secretion. However, two key questions remain. First, is …

Aims/hypothesis Endothelial cells are considered to be essential for normal pancreatic beta
cell function. However, there have been no reports showing their importance for beta cell …

Previously, we found that the islet of pancreas stained with a antibody against the vascular
permeability factor (VPF; also known as vascular endothelial growth factor, VEGF) protein …

To investigate molecular mechanisms controlling islet vascularization and revascularization
after transplantation, we examined pancreatic expression of three families of angiogenic …

Aims/hypothesis Vascular endothelial growth factor (VEGF) has been recognised by loss-of-
function experiments as a pleiotropic factor with importance in embryonic pancreas …