Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages

JE McLaren, DR Michael, IA Guschina, JL Harwood… - Lipids, 2011 - Springer
There is evidence that long chain n-3 PUFA (such as from fish oils) provide atheroprotection
through, in part, changes in macrophage function although it has not been fully determined …

Omega-3 fatty acids and leukocyte-endothelium adhesion: Novel anti-atherosclerotic actions

EJ Baker, MH Yusof, P Yaqoob, EA Miles… - Molecular Aspects of …, 2018 - Elsevier
Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial
function becomes dysregulated, the risk of developing atherosclerosis increases …

Eicosapentaenoic acid membrane incorporation impairs cholesterol efflux from cholesterol-loaded human macrophages by reducing the cholesteryl ester mobilization …

N Fournier, G Sayet, B Vedie, M Nowak… - … et Biophysica Acta (BBA …, 2017 - Elsevier
A diet containing a high n− 3/n− 6 polyunsaturated fatty acids (PUFA) ratio has
cardioprotective properties. PUFAs incorporation into membranes influences the function of …

Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation

A Takashima, D Fukuda, K Tanaka, Y Higashikuni… - Atherosclerosis, 2016 - Elsevier
Background and aims Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are
major components of n-3 polyunsaturated fatty acids (n-3 PUFAs) which inhibit …

Omega-3 polyunsaturated fatty acids: anti-inflammatory and anti-hypertriglyceridemia mechanisms in cardiovascular disease

T Shibabaw - Molecular and Cellular Biochemistry, 2021 - Springer
Cardiovascular disease (CVD) is the world's most recognized and notorious cause of death.
It is known that increased triglyceride-rich lipoproteins (TRLs) and remnants of triglyceride …

Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids

R Adili, M Hawley, M Holinstat - Prostaglandins & other lipid mediators, 2018 - Elsevier
Thrombosis is the most common underlying pathology responsible for morbidity and
mortality in cardiovascular disease (CVD). Platelet adhesion, activation, and aggregation …

Polyunsaturated Fatty Acids and Atherosclerosis: Insights from Pre‐Clinical Studies

DP Ramji - European Journal of Lipid Science and Technology, 2019 - Wiley Online Library
Atherosclerosis and its complications are responsible for more global deaths than any other
disease. Atherosclerosis is a chronic inflammatory disease of medium and large arteries that …

Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects

DS Kelley, Y Adkins - Proceedings of the Nutrition Society, 2012 - cambridge.org
We have reviewed effects of long chain (LC) n-3 PUFA on markers of atherosclerosis in
human subjects with a focus on individual effects of EPA and DHA. Initial results from …

Effects of n-3 fatty acids on growth and survival of J774 macrophages

DJ Fyfe, M Abbey - Prostaglandins, Leukotrienes and Essential Fatty Acids …, 2000 - Elsevier
To further understand potential mechanisms underlying the protective effects of
eicosapentanoic acid (EPA) against atherosclerosis, J774 macrophages were used to …

Protective role of n6/n3 PUFA supplementation with varying DHA/EPA ratios against atherosclerosis in mice

L Liu, Q Hu, H Wu, Y Xue, L Cai, M Fang, Z Liu… - The Journal of nutritional …, 2016 - Elsevier
The effects of n3 polyunsaturated fatty acids (PUFA) on cardiovascular disease are
controversial. We currently explored the effects of various ratios of docosahexaenoic acid …