In obesity, accumulation of lipid in nonadipose tissues, or lipotoxicity, is associated with
endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and ultimately apoptosis. We …

This review summarizes some of the recent advances in obesity research and describes
how we and others have built upon these findings to better understand the impact of obesity …

Fatty acids such as palmitic acid at high levels are known to induce endoplasmic reticulum
(ER) stress and lipotoxicity in numerous cell types and thereby contribute to cellular …

Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in
women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises …

Maternal diet during pregnancy influences the later life reproductive potential of female
offspring. We investigate the molecular mechanisms underlying the depletion of ovarian …

OBJECTIVE: To determine whether the high lipid content of human follicular fluid influences
oocyte maturation. DESIGN: Mouse oocytes as substitutes for human oocytes were exposed …

Obesity adversely affects reproduction and results in oocyte defects in both mice and
humans. In the present study we used a mouse model to examine whether the adverse …

Excess calorie consumption, particularly of a diet high in fat, is a risk factor for both obesity
and reproductive disorders. Animal model studies indicate that elevated dietary fat can …

Over-nutrition in females causes altered fetal growth during pregnancy and permanently
programs the metabolism of offspring; however, the temporal and mechanistic origins of …

Obesity was shown to cause reproductive dysfunctions such as reduced conception,
infertility and early pregnancy loss. However, the possible effects of obesity on oocyte quality …