CD40-mediated interactions play an important role in the response to infections,
transplantation, and cancer by affecting the development, activation, proliferation and …

The interaction of CD40 expressed by immunocompetent cells with its ligand CD154 on the
surface of T-helper cells plays a crucial role in the immune response. Recently, the presence …

Abstract CD40/CD40 ligand (CD40L) interaction plays an essential role in cell-mediated
immune responses. We examined whether expression of CD40L in murine lung carcinoma …

CD40 ligation has been shown to induce antitumor effects in mice and cancer patients. Most
of the studies have focused on the ability of an agonistic anti-CD40 mAb to either directly kill …

The interaction between CD40 ligand (CD40L, CD154) and its receptor CD40 has been
implicated in the establishment of cell-mediated immunity as well as humoral immune …

Abstract The CD40–CD40 ligand (CD40L) system is of pivotal importance in the immune
response via interactions between T cells and antigen-presenting cells. Recent reports have …

Background CD40, a cell surface molecule, is expressed on B-cell malignancies and many
different solid tumors. It is capable of mediating diverse biological phenomena such as the …

CD40 is a costimulatory molecule widely expressed by immune cells and by neoplastic cells
of different histotypes. Engagement of surface CD40 mediates different effects depending on …

CD40 is present on B cells, monocytes, dendritic cells, and endothelial cells, as well as a
variety of neoplastic cell types, including carcinomas. CD40 stimulation by an antibody has …

CD40 is a 50 kDa molecule, a member of the tumor necrosis factor/nerve growth factor
receptor family. It is expressed on B cells, monocytes, dendritic cells and various malignant …