Altered trafficking of CD8+ memory T cells after implantation of rapamycin-eluting stents in patients with coronary artery disease

G Sardella, D Accapezzato, A Di Roma, V Francavilla… - Immunology letters, 2005 - Elsevier
Aim of this study was to investigate the effects of implantation of different coronary drug-
eluting stents on trafficking of central (TCM) or effector (TEM) memory T cells in the coronary …

Comparison between sirolimus-and paclitaxel-eluting stent in T-cell subsets redistribution

G Sardella, L De Luca, A Di Roma, G De Persio… - The American journal of …, 2006 - Elsevier
We sought to investigate the effects of 2 different coronary drug-eluting stents on the
distribution of central or effector memory T cells circulating in the coronary sinus of patients …

CD4+ CD25highCD127low regulatory T cells in patients with stable angina and their dynamics after intracoronary sirolimus-eluting stent implantation

AV Potekhina, SI Provatorov, VO Sokolov… - Human Immunology, 2011 - Elsevier
Rapamycin contributes to the expansion of regulatory T cells (Tregs) in vitro. We
investigated CD4+ CD25 high CD127 low Treg level dynamics as well as the major …

Frequency of naturally-occurring regulatory T cells is reduced in patients with ST-segment elevation myocardial infarction

G Sardella, L De Luca, V Francavilla, D Accapezzato… - Thrombosis research, 2007 - Elsevier
BACKGROUND: Naturally-occurring regulatory T cells (Treg) constitute a mature T-cell
population characterized phenotypically by co-expression of CD4 and CD25high surface …

Mobilization of CD34-Positive bone marrow-derived cells after coronary stent implantation: Impact on restenosis

T Inoue, Y Hikichi, T Hirase, H Komoda, R Sohma… - 2006 - Am Heart Assoc
Backgrounds: Recently, there is accumulating evidence that bone marrow-derived stem
cells are capable of differentiating into vascular cells. After vascular injury, it is hypothesized …

Mobilization of CD34-Positive Bone Marrow–Derived Cells After Coronary Stent Implantation: Impact on Restenosis

T Inoue, M Sata, Y Hikichi, R Sohma, D Fukuda… - Circulation, 2007 - Am Heart Assoc
Background—Recently, accumulating evidence has indicated that bone marrow–derived
stem cells are capable of differentiating into vascular cells. It has been hypothesized that the …

[HTML][HTML] Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells

C Wang, T Yi, L Qin, RA Maldonado… - The Journal of …, 2013 - Am Soc Clin Investig
Human graft endothelial cells (ECs) can act as antigen-presenting cells to initiate allograft
rejection by host memory T cells. Rapamycin, an mTOR inhibitor used clinically to suppress …

[HTML][HTML] T cells in cardiac allograft vasculopathy are skewed to memory Th-1 cells in the presence of a distinct Th-2 population

MC Hagemeijer, MFM Van Oosterhout… - American Journal of …, 2008 - Elsevier
Cardiac allograft vasculopathy (CAV) in heart transplantation (HTx) patients remains the
major complication for long-term survival, due to concentric neointima hyperplasia induced …

T cell recognition and killing of vascular smooth muscle cells in acute coronary syndrome

S Pryshchep, K Sato, JJ Goronzy… - Circulation research, 2006 - Am Heart Assoc
Loss of vascular smooth muscle cells (VSMCs) has been proposed to destabilize the
atherosclerotic plaque and contribute to plaque rupture, superimposed thrombosis, and …

[HTML][HTML] Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo

J Hester, A Schiopu, SN Nadig, KJ Wood - American Journal of …, 2012 - Elsevier
Regulatory T cells (T reg) are currently being tested in clinical trials as a potential therapy in
cell and solid organ transplantation. The immunosuppressive drug rapamycin has been …