Stem cell‐mediated tissue repair is a promising approach for many diseases. Mammalian
intestine is an actively regenerating tissue such that epithelial cells are constantly shedding …

Stem cell division is essential for tissue integrity during growth, aging, and pathogenic
assaults. Adult gastrointestinal tract encounters numerous stimulations, and impaired tissue …

Drosophila has long been an excellent model organism for studying stem cell biology.
Notably, studies of Drosophila's germline stem cells have been instrumental in developing …

Epithelial cells of the digestive tracts of most animals are short-lived, and are constantly
replenished by the progeny of long-lived, resident intestinal stem cells. Proper regulation of …

The gastrointestinal (GI) tract renews frequently to sustain nutrient digestion and absorption
in the face of consistent tissue stress. In many species, proliferative intestinal stem cells …

The digestive systems in mammals and Drosophila are quite different in terms of their
complexity and organization, but their biological functions are similar. The Drosophila …

Intestinal epithelial renewal is mediated by intestinal stem cells (ISCs) that exist in a state of
neutral drift, wherein individual ISC lineages are regularly lost and born but ISC numbers …

Many adult tissues and organs are maintained by resident stem cells that are activated in
response to injury but the mechanisms that regulate stem cell activity during regeneration …

Many adult tissues and organs including the intestine rely on resident stem cells to maintain
homeostasis and regeneration. In mammals, the progenies of intestinal stem cells (ISCs) …

Stem cells have essential functions in the development and maintenance of our organs.
Improper regulation of adult stem cells and tissue homeostasis can result in cancers and …