Summary Acetaminophen (N-acetyl-p-aminophenol, APAP) overdose causes hepatotoxicity,
even liver failure, and oxidative stress plays pivotal role in its pathogenesis. Nicotinic acid …

Acetaminophen (APAP) overdose causes acute liver injury (ALI). Nicotinamide adenine
dinucleotide (NAD) is an essential coenzyme, and NAD+ is oxidized type which synthesized …

The aim of this study was to investigate the protective effect of nicotinamide adenine
dinucleotide (NAD+) against acute liver injury (ALI) induced by acetaminophen (APAP) …

Hepatotoxicity due to acetaminophen (APAP) overdose is a leading cause of drug-induced
acute liver failure in clinic. Chlorogenic acid (CGA), a dietary polyphenol, was reported to …

Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to
overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) …

Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) is a
natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by …

Acetaminophen (APAP) overdose can produce hepatotoxicity and consequently liver
damage. This study investigated the hepatoprotective impacts of nicorandil on hepatic …

Acute liver failure induced by acetaminophen (APAP) overdose is the main cause of drug-
induced liver injury (DILI). Caffeic acid (CA) is a phenolic compound from many natural …

To explore the action time and molecular mechanism underlying the effect of
acetaminophen (APAP) on liver injury. APAP was used to establish drug-induced liver injury …

Rosmarinic acid (RA) is a natural polyphenol with various biological activities, such as anti-
oxidative, anti-fibrotic, and hepatoprotective properties. The objective of this study was to …