Background: Previous research indicates that antidepressants can restore the balance
between negative and positive emotional processing early in treatment, indicating a role of …

Antidepressants remediate negative biases in emotional processing early in treatment, prior
to mood improvement. However, the effects on reward processing potentially relevant to the …

BackgroundWe have previously shown that the selective serotonergic reuptake inhibitor,
citalopram, reduces the neural response to reward and aversion in healthy volunteers. We …

Background: We assessed the therapeutic effects of bupropion SR and placebo on mood
and anxiety symptoms derived from the tripartite model of mood. Based on evidence …

Rationale Bupropion is used for major depressive disorder, smoking cessation aid, and
obesity. It blocks reuptake of dopamine and noradrenaline and antagonizes nicotinic …

Background The opioid drug buprenorphine has been shown to modify responses to
emotional stimuli and may have antidepressant properties. In preclinical studies, it shows …

Bupropion is an effective abstinence aid for cessation of smoking and possibly other drug
use as well. There is evidence that bupropion improves attention and impulse control in …

Rationale Bupropion is an atypical antidepressant and the only non-nicotine-based therapy
approved for smoking cessation. Its use has raised much debate as to how a non-nicotine …

Objective: Acute administration of an antidepressant increases positive affective processing
in healthy volunteers, an effect that may be relevant to the therapeutic actions of these …

Background: Prior imaging studies suggest that patients with major depressive disorder
have abnormalities in frontal and limbic neural circuitry including the amygdala, which is …