[HTML] nature.com

[HTML][HTML] mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior

P Bäckström, D Bachteler, S Koch, P Hyytiä… - …, 2004 - nature.com
The glutamatergic system plays an important role in mediating neurobehavioral effects of
ethanol. Metabotropic glutamate receptors subtype 5 (mGluR5) are modulators of …
被引用次数：287 相关文章 所有 9 个版本
[PDF] researchgate.net

The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) …

JP Schroeder, DH Overstreet, CW Hodge - Psychopharmacology, 2005 - Springer
Rationale Recent research indicates that blockade of mGluR5 modifies the reinforcing
properties of ethanol. Objectives The present studies examined the effects of mGluR5 …
被引用次数：189 相关文章 所有 12 个版本
[HTML] nih.gov

The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice

CW Hodge, MF Miles, AC Sharko, RA Stevenson… - …, 2006 - Springer
Rationale Many of the biochemical, physiological, and behavioral effects of ethanol are
known to be mediated by ionotropic glutamate receptors. Emerging evidence implicates …
被引用次数：158 相关文章 所有 16 个版本
[HTML] nih.gov

Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of …

N Sidhpura, F Weiss, R Martin-Fardon - Biological psychiatry, 2010 - Elsevier
BACKGROUND: Growing evidence supports a role of metabotropic glutamate receptors
(mGluRs) in ethanol reinforcement, ethanol seeking, and ethanol withdrawal. To extend the …
被引用次数：119 相关文章 所有 9 个版本
[HTML] nature.com

[HTML][HTML] Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR2/3 agonist LY379268 and increased functional activity of mGluR2/3 in rats with …

PR Kufahl, R Martin-Fardon, F Weiss - Neuropsychopharmacology, 2011 - nature.com
Recent findings implicate group II metabotropic glutamate receptors (mGluR 2/3) in the
reinforcing and dependence-inducing actions of ethanol and identify these receptors as …
被引用次数：72 相关文章 所有 14 个版本
[HTML] nih.gov

Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high …

J Besheer, JJM Grondin, R Cannady, AC Sharko… - Biological …, 2010 - Elsevier
BACKGROUND: Systemic modulation of Group I and II metabotropic glutamate receptors
(mGluRs) regulate ethanol self-administration in a variety of animal models. Although these …
被引用次数：140 相关文章 所有 16 个版本
[HTML] nih.gov

Regulation of motivation to self‐administer ethanol by mGluR5 in alcohol‐preferring (P) rats

J Besheer, S Faccidomo, JJM Grondin… - Alcoholism: Clinical …, 2008 - Wiley Online Library
Background: Emerging evidence indicates that Group I metabotropic glutamate receptors
(mGluR1 and mGluR5) differentially regulates ethanol self‐administration in several rodent …
被引用次数：112 相关文章 所有 9 个版本
[PDF] researchgate.net

Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties

KD Lominac, Z Kapasova, RA Hannun… - Drug and alcohol …, 2006 - Elsevier
Blockade of the mGluR5 subtype of Group 1 metabotropic glutamate receptor (mGluRs)
reduces the rewarding effects of ethanol (EtOH), while the effects of mGluR1a blockade …
被引用次数：138 相关文章 所有 9 个版本
[HTML] nih.gov

Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082

MC Salling, S Faccidomo, CW Hodge - Pharmacology Biochemistry and …, 2008 - Elsevier
Emerging evidence indicates that specific metabotropic glutamate receptors (mGluRs)
modulate ethanol self-administration. In general, inhibition of glutamate transmission …
被引用次数：62 相关文章 所有 8 个版本
[PDF] oup.com

Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions

YA Blednov, R Adron Harris - International Journal of …, 2008 - academic.oup.com
Recent studies have demonstrated that metabotropic glutamate receptor 5 (mGluR5)
antagonists decrease alcohol self-administration and suggest that the anti-craving …
被引用次数：162 相关文章 所有 13 个版本