Introduction Germline CDH1 mutations, classically associated with hereditary diffuse gastric
cancer (HDGC), also imply an increased lifetime risk of developing lobular breast cancer …

Pathogenic CDH1 germline mutations are associated with lobular breast cancer in the so-
called hereditary lobular breast cancer (HLBC) syndrome, without apparent correlation with …

Introduction CDH1 predisposes primarily to diffuse gastric cancer (DGC). Multiple DGC
cases in a family, DGC at a young age in an individual or the combination of DGC …

Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer
(LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A …

Background Germline mutations in CDH1 are associated with hereditary diffuse gastric
cancer; lobular breast cancer also occurs excessively in families with such condition …

Hereditary diffuse gastric cancer is an autosomal dominant inherited disease associated of
CDH1 germline mutations (that encodes for the E-cadherin protein), and lobular breast …

Importance Hereditary cancer risk is informed by the presence of a germline gene variant
more so than by family history of cancer. Objective To assess gastric cancer risk among …

CDH1 gene mutations have been found to be associated with diffuse type gastric cancer
and invasive lobular carcinoma (ILC) of the breast. To the best of our knowledge, this is the …

Background Gastric cancer is the fifth most prevalent and the third most lethal cancer
worldwide, causing approximately 720,000 deaths annually. Although most cases of gastric …

E-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse
gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an …