Proteomics of the rat myocardium during development of type 2 diabetes mellitus reveals progressive alterations in major metabolic pathways
AV Edhager, JA Povlsen, B Løfgren… - Journal of Proteome …, 2018 - ACS Publications
Congestive heart failure and poor clinical outcome after myocardial infarction are known
complications in patients with type-2 diabetes mellitus (T2DM). Protein alterations may be …
complications in patients with type-2 diabetes mellitus (T2DM). Protein alterations may be …
Membrane proteomics of impaired energetics and cytoskeletal disorganization in elderly diet-induced diabetic mice
CL Hung, SH Pan, CL Han, CW Chang… - Journal of proteome …, 2017 - ACS Publications
Diabetic cardiomyopathy is a well-recognized complication of diabetes, but its
pathophysiology is unclear. We aimed to investigate the mechanisms underlying cardiac …
pathophysiology is unclear. We aimed to investigate the mechanisms underlying cardiac …
Proteome changes in the myocardium of experimental chronic diabetes and hypertension: role of PPARα in the associated hypertrophy
S Ares-Carrasco, B Picatoste, E Camafeita… - Journal of …, 2012 - Elsevier
Diabetes with or without the presence of hypertension damages the heart. However, there is
currently a lack of information about these associated pathologies and the alteration of …
currently a lack of information about these associated pathologies and the alteration of …
Post‐translational modifications of the cardiac proteome in diabetes and heart failure
AR Wende - PROTEOMICS–Clinical Applications, 2016 - Wiley Online Library
Cardiovascular complications are the leading cause of death in diabetic patients. Decades
of research has focused on altered gene expression, altered cellular signaling, and altered …
of research has focused on altered gene expression, altered cellular signaling, and altered …
Proteomic changes in the heart of diet-induced pre-diabetic mice
D Cruz-Topete, EO List, S Okada, B Kelder… - Journal of …, 2011 - Elsevier
The development of type 2 diabetes (T2D) is strongly associated with obesity. In humans,
T2D increases the risk for end organ complications. Among these, heart disease has been …
T2D increases the risk for end organ complications. Among these, heart disease has been …
Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathy
M Hamblin, DB Friedman, S Hill, RM Caprioli… - Journal of molecular and …, 2007 - Elsevier
Diabetic cardiomyopathy has been documented as an underlying etiology of heart failure
(HF) among diabetics. Although oxidative stress has been proposed to contribute to diabetic …
(HF) among diabetics. Although oxidative stress has been proposed to contribute to diabetic …
Proteomic analysis suggests altered mitochondrial metabolic profile associated with diabetic cardiomyopathy
Diabetic cardiomyopathy (DbCM) occurs independently of cardiovascular diseases or
hypertension, leading to heart failure and increased risk for death in diabetic patients. To …
hypertension, leading to heart failure and increased risk for death in diabetic patients. To …
Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes
X Shen, S Zheng, V Thongboonkerd… - American Journal …, 2004 - journals.physiology.org
Diabetic cardiomyopathy is a common complication leading to heightened risk of heart
failure and death. In the present report, we performed proteomic analysis on total cardiac …
failure and death. In the present report, we performed proteomic analysis on total cardiac …
Proteomic analysis of hearts from Akita mice suggests that increases in soluble epoxide hydrolase and antioxidative programming are key changes in early stages of …
S Dewey, X Lai, FA Witzmann, M Sohal… - Journal of proteome …, 2013 - ACS Publications
Cardiovascular disease is the leading cause of diabetic morbidity with more than 10% of
type 1 diabetes mellitus (T1DM) patients dying before they are 40 years old. This study …
type 1 diabetes mellitus (T1DM) patients dying before they are 40 years old. This study …
Simulated hyperglycemia in rat cardiomyocytes: a proteomics approach for improved analysis of cellular alterations
Diabetic hyperglycemia can lead to stress‐related cellular apoptosis of cardiac tissue.
However, the mechanism by which hyperglycemia inflicts this damage on the structure and …
However, the mechanism by which hyperglycemia inflicts this damage on the structure and …
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