Proteomics of the rat myocardium during development of type 2 diabetes mellitus reveals progressive alterations in major metabolic pathways

AV Edhager, JA Povlsen, B Løfgren… - Journal of Proteome …, 2018 - ACS Publications
Congestive heart failure and poor clinical outcome after myocardial infarction are known
complications in patients with type-2 diabetes mellitus (T2DM). Protein alterations may be …

Membrane proteomics of impaired energetics and cytoskeletal disorganization in elderly diet-induced diabetic mice

CL Hung, SH Pan, CL Han, CW Chang… - Journal of proteome …, 2017 - ACS Publications
Diabetic cardiomyopathy is a well-recognized complication of diabetes, but its
pathophysiology is unclear. We aimed to investigate the mechanisms underlying cardiac …

Proteome changes in the myocardium of experimental chronic diabetes and hypertension: role of PPARα in the associated hypertrophy

S Ares-Carrasco, B Picatoste, E Camafeita… - Journal of …, 2012 - Elsevier
Diabetes with or without the presence of hypertension damages the heart. However, there is
currently a lack of information about these associated pathologies and the alteration of …

Post‐translational modifications of the cardiac proteome in diabetes and heart failure

AR Wende - PROTEOMICS–Clinical Applications, 2016 - Wiley Online Library
Cardiovascular complications are the leading cause of death in diabetic patients. Decades
of research has focused on altered gene expression, altered cellular signaling, and altered …

Proteomic changes in the heart of diet-induced pre-diabetic mice

D Cruz-Topete, EO List, S Okada, B Kelder… - Journal of …, 2011 - Elsevier
The development of type 2 diabetes (T2D) is strongly associated with obesity. In humans,
T2D increases the risk for end organ complications. Among these, heart disease has been …

Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathy

M Hamblin, DB Friedman, S Hill, RM Caprioli… - Journal of molecular and …, 2007 - Elsevier
Diabetic cardiomyopathy has been documented as an underlying etiology of heart failure
(HF) among diabetics. Although oxidative stress has been proposed to contribute to diabetic …

Proteomic analysis suggests altered mitochondrial metabolic profile associated with diabetic cardiomyopathy

KP Gomes, AS Jadli, LGN de Almeida… - Frontiers in …, 2022 - frontiersin.org
Diabetic cardiomyopathy (DbCM) occurs independently of cardiovascular diseases or
hypertension, leading to heart failure and increased risk for death in diabetic patients. To …

Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes

X Shen, S Zheng, V Thongboonkerd… - American Journal …, 2004 - journals.physiology.org
Diabetic cardiomyopathy is a common complication leading to heightened risk of heart
failure and death. In the present report, we performed proteomic analysis on total cardiac …

Proteomic analysis of hearts from Akita mice suggests that increases in soluble epoxide hydrolase and antioxidative programming are key changes in early stages of …

S Dewey, X Lai, FA Witzmann, M Sohal… - Journal of proteome …, 2013 - ACS Publications
Cardiovascular disease is the leading cause of diabetic morbidity with more than 10% of
type 1 diabetes mellitus (T1DM) patients dying before they are 40 years old. This study …

Simulated hyperglycemia in rat cardiomyocytes: a proteomics approach for improved analysis of cellular alterations

M Warda, HK Kim, N Kim, JB Youm, SH Kang… - …, 2007 - Wiley Online Library
Diabetic hyperglycemia can lead to stress‐related cellular apoptosis of cardiac tissue.
However, the mechanism by which hyperglycemia inflicts this damage on the structure and …