Astrocytes detect and upregulate transmission at inhibitory synapses of somatostatin interneurons onto pyramidal cells

M Matos, A Bosson, I Riebe, C Reynell, J Vallée… - Nature …, 2018 - nature.com
Astrocytes are important regulators of excitatory synaptic networks. However, astrocytes
regulation of inhibitory synaptic systems remains ill defined. This is particularly relevant …

Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes

L Mariotti, G Losi, A Lia, M Melone… - Nature …, 2018 - nature.com
The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to
generate the functional heterogeneity that characterizes brain circuits. Whether this diversity …

Hippocampal somatostatin interneurons, long-term synaptic plasticity and memory

E Honoré, A Khlaifia, A Bosson… - Frontiers in neural circuits, 2021 - frontiersin.org
A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons.
These complex inhibitory interconnections largely contribute to the tight modulation of …

Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons

Z Tan, Y Liu, W Xi, H Lou, L Zhu, Z Guo, L Mei… - Nature …, 2017 - nature.com
Astrocyte responds to neuronal activity with calcium waves and modulates synaptic
transmission through the release of gliotransmitters. However, little is known about the direct …

Somatostatin-expressing inhibitory interneurons in cortical circuits

I Yavorska, M Wehr - Frontiers in neural circuits, 2016 - frontiersin.org
Cortical inhibitory neurons exhibit remarkable diversity in their morphology, connectivity, and
synaptic properties. Here, we review the function of somatostatin-expressing (SOM) …

Astrocytes modulate sensory-evoked neuronal network activity

J Lines, ED Martin, P Kofuji, J Aguilar… - Nature communications, 2020 - nature.com
While neurons principally mediate brain function, astrocytes are emerging as cells with
important neuromodulatory actions in brain physiology. In addition to homeostatic roles …

Neocortical somatostatin neurons reversibly silence excitatory transmission via GABAb receptors

J Urban-Ciecko, EE Fanselow, AL Barth - Current Biology, 2015 - cell.com
Background Understanding the dynamic range for excitatory transmission is a critical
component of building a functional circuit diagram for the mammalian brain. Excitatory …

Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network

SA Booker, H Harada, C Elgueta, J Bank, M Bartos… - Elife, 2020 - elifesciences.org
Information processing in cortical neuronal networks relies on properly balanced excitatory
and inhibitory neurotransmission. A ubiquitous motif for maintaining this balance is the …

Robust but delayed thalamocortical activation of dendritic-targeting inhibitory interneurons

Z Tan, H Hu, ZJ Huang… - Proceedings of the …, 2008 - National Acad Sciences
GABA-releasing cortical interneurons are crucial for the neural transformations underlying
sensory perception, providing “feedforward” inhibition that constrains the temporal window …

Target-specific effects of somatostatin-expressing interneurons on neocortical visual processing

JCH Cottam, SL Smith, M Häusser - Journal of Neuroscience, 2013 - Soc Neuroscience
A diverse array of interneuron types regulates activity in the mammalian neocortex. Two of
the most abundant are the fast-spiking, parvalbumin-positive (PV+) interneurons, which …