A very significant density of adenosine A2A receptors (A2ARs) is present in the striatum,
where they are preferentially localized postsynaptically in striatopallidal medium spiny …

Striatal adenosine A2A receptors (A2ARs) are highly expressed in medium spiny neurons
(MSNs) of the indirect efferent pathway, where they heteromerize with dopamine D2 …

Adenosine receptors are G protein-coupled receptors (GPCRs) that mediate the
physiological functions of adenosine. In the central nervous system adenosine A2A …

A2A adenosine receptors (A2ARs) are expressed with the greatest abundance in the
striatum and other nuclei of the basal ganglia. The segregated expression of A2ARs on the …

Basal ganglia processing results from a balanced activation of direct and indirect striatal
efferent pathways, which are controlled by dopamine D1 and D2 receptors, respectively …

There is now growing interest in the functional role of adenosine A2A receptors. Their
distribution within the brain is restricted in the basal ganglia, particularly abundant in the …

Adenosine A2A receptors (A2ARs) are highly concentrated in the striatum. Two
pharmacological different functional populations of A2ARs have been recently described …

Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

Several selective antagonists for adenosine A2A receptors (A2AR) are currently under
evaluation in clinical trials (phases I to III) to treat Parkinson's disease, and they will probably …

In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …