The Effect of Hypothermia and Hyperthermia on Photodynamic Therapy of Normal Brain: 141

MO Dereski, L Madigan, M Chopp - Neurosurgery, 1995 - journals.lww.com
Abstract THE EFFECT OF whole body hyperthermia and hypothermia in conjunction with
photodynamic therapy (PDT) was determined on normal rat brain. Hyperthermia animals …

Toxicity of photodynamic therapy with photofrin in the normal rat brain

Y Ji, SK Powers, JT Brown, D Walstad… - Lasers in surgery and …, 1994 - Wiley Online Library
The widespread acceptance of photodynamic therapy (PDT), a potential adjuvant brain
tumor therapy under clinical evaluation since 1980, has been partially restrained by its …

Depth measurements and histopathological characterization of photodynamic therapy generated normal brain necrosis as a function of incident optical energy dose

MO Dereski, M Chopp, JH Garcia… - Photochemistry and …, 1991 - Wiley Online Library
The response of normal brain to photodynamic therapy (PDT) was investigated in 62 Fisher
rats. The animals were injected ip with Photofrin II (12.5 mg/kg). Forty‐eight hours following …

Experimental research photodynamic effects in perifocal, oedematous brain tissue

C Goetz, A Hasan, W Stummer, A Heimann… - Acta …, 2002 - Springer
Summary. Background: Photodynamic therapy (PDT) has been under discussion as
additional treatment option for malignant gliomas. However, damage not only to tumour …

Photodynamic therapy of intracranial tissues: a preclinical comparative study of four different photosensitizers

L LILGE, BC WILSON - Journal of clinical laser medicine & surgery, 1998 - liebertpub.com
Objective: The effectiveness of four different photosensitizers for intracranial photodynamic
therapy (PDT) of normal brain tissues and an intracranial tumor was investigated in rabbits …

The role of photodynamic therapy in posterior fossa brain tumors: A preclinical study in a canine glioma model

HT Whelan, MH Schmidt, AD Segura… - Journal of …, 1993 - thejns.org
✓ Photodynamic therapy was studied in dogs with and without posterior fossa
glioblastomas. This mode of therapy consisted of intravenous administration of Photofrin-II at …

Photodynamic therapy using pheophorbide a and Nd: YAG laser

I Fujishima, T SAKAI, T TANAKA, H RYU… - Neurologia medico …, 1991 - jstage.jst.go.jp
The authors describe a new photodynamic therapy (PDT) method for malignant brain
tumors. Pheophorbide α(Ph-a), the photosensitizer, has low toxicity, causes no skin …

Normal brain tissue response to photodynamic therapy: histology, vascular permeability and specific gravity

MO Dereski, M Chopp, Q Chen… - Photochemistry and …, 1989 - Wiley Online Library
The response of photodynamic therapy on normal brain was investigated in 140 Fisher rats.
The rats were injected ip with Photofrin II (12.5 mg/kg) and 48 h later the dural area over the …

Photodynamic therapy within edematous brain tissue: considerations on sensitizer dose and time point of laser irradiation

W Stummer, A Hassan, O Kempski, C Goetz - Journal of Photochemistry …, 1996 - Elsevier
Photosensitizer is known to spread with vasogenic edema fluid arising from a cerebral
lesion (Neurosurg 3: 1075–1082, 1993), which may be essential for sensitizing malignant …

The effect of light fluence rate in photodynamic therapy of normal rat brain

Q Chen, M Chopp, MO Dereski… - Radiation …, 1992 - meridian.allenpress.com
This paper reports the effect of incident light fluence rate on the depth to which necrotic
lesions are produced by photodynamic therapy (PDT) in the brains of normal Fisher rats …