The development of chronic pain is typically predicated by neuroplastic changes within the
spinal cord in response to persistent noxious stimuli, termed central sensitization …

Cutaneous sensibility and neurogenic vasodilatation (flare) were measured before, during
and after long-term topical application of capsaicin in humans. Each subject applied a …

Capsaicin-containing plant extracts have been used as topical treatments for a variety of
pain syndromes for many centuries. Current products containing capsaicin in low …

Localized neuropathic pain can be relieved following the topical application of high-
concentration capsaicin. This clinical effect is thought to be related to the temporary …

Introduction Topical capsaicin is commonly employed to experimentally induce central
sensitization (CS) in humans. While previous studies have investigated the effect of skin …

Background At high concentration, the TRPV‐1 agonist capsaicin de‐sensitizes nociceptors
and reduces the intra‐epidermal nerve density. Methods We investigated the effects of a 5× …

Topically applied high-concentration capsaicin induces reversible dermo-epidermal
denervation and depletion of capsaicin-sensitive nociceptors. This causes desensitization of …

Background This study investigated (a) if a prolonged noxious stimulus (24‐hr topical
capsaicin) in healthy adults would impair central pain inhibitory and facilitatory systems …

The present study was undertaken to characterize spontaneous (ie, nonevoked) pain
behaviors (flinching, biting/licking) produced by local injections of capsaicin into the rat …

The TRPV1 receptor is known to play a role in nociceptive transmission in multiple organ
systems, usually in response to the pain of inflammation. TRPV1 antagonism has so far …