Cerebral arterioles have been regarded as the primary sites of autoregulatory responses,
whereas the role of large arteries in the cerebral autoregulation is poorly understood. The …

The goal of this study was to examine hemodynamic mechanisms that contribute to regional
differences in autoregulation during acute hypertension. We measured blood flow …

This study was designed to determine age-related changes in autoregulatory responses of
the brain stem circulation in vivo. In anesthetized adult (4 to 6 months, n= 8) and aged (24 to …

Previous studies have demonstrated a significant pressure gradient from carotid artery to
pial or middle cerebral arteries. This pressure gradient suggests that large cerebral arteries …

Cerebral large arteries dilate actively around the lower limits of CBF autoregulation,
mediated at least partly by nitric oxide, and maintain CBF during severe hypotension. We …

The purpose of this study was to examine hemodynamic mechanisms of protection of the
blood-brain barrier in the brain stem during acute hypertension. We used a new method to …

The purpose of this study was to examine regional autoregulation of blood flow in the brain
during acute hypertension. In anesthetized cats severe hypertension increased blood flow …

The responses of cerebral precapillary vessels to changes in arterial blood pressure were
studied in anesthetized cats equipped with cranial windows for the direct observation of the …

Experimental advances during the last decade have greatly expanded our knowledge of
mechanisms that control cerebral blood flow. In addition to local metabolites, many other …

Chronic hypertension profoundly alters the function and structure of cerebral blood vessels.
The pressure—flow relationship in the cerebral circulation is altered in chronic hypertension …