[PDF][PDF] Anti-cancer mechanisms of action of therapeutic alternating electric fields (tumor treating fields [TTFields])

S Shams, CB Patel - Journal of molecular cell biology, 2022 - academic.oup.com
Despite improved survival outcomes across many cancer types, the prognosis remains grim
for certain solid organ cancers including glioblastoma and pancreatic cancer. Invariably in …

Tumor treating fields: a comprehensive overview of the underlying molecular mechanism

P Hong, N Kudulaiti, S Wu, J Nie… - Expert review of …, 2022 - Taylor & Francis
Introduction As a novel treatment modality, tumor treating fields (TTFields) exert low-
intensity, medium-frequency electric fields on tumor cells. TTFields' effectiveness and safety …

[HTML][HTML] Current status of the preclinical evaluation of alternating electric fields as a form of cancer therapy

C Pohling, H Nguyen, E Chang, KE Schubert, Y Nie… - …, 2023 - Elsevier
Exposing cancer cells to alternating electric fields of 100-300 kHz frequency and 1-4 V/cm
strength has been shown to significantly reduce cancer growth in cell culture and in human …

Tumor-treating fields: a fourth modality in cancer treatment

EJ Mun, HM Babiker, U Weinberg, ED Kirson… - Clinical Cancer …, 2018 - AACR
Despite major advances in therapy, cancer continues to be a leading cause of mortality. In
addition, toxicities of traditional therapies pose a significant challenge to tolerability and …

Therapeutic potential of tumor treating fields for malignant brain tumors

Y Zhou, X Xing, J Zhou, H Jiang, P Cen, C Jin… - Cancer …, 2023 - Wiley Online Library
Background Malignant brain tumors are among the most threatening diseases of the central
nervous system, and despite increasingly updated treatments, the prognosis has not been …

[HTML][HTML] Alternating electric fields (tumor-treating fields therapy) can improve chemotherapy treatment efficacy in non-small cell lung cancer both in vitro and in vivo

M Giladi, U Weinberg, RS Schneiderman, Y Porat… - Seminars in …, 2014 - Elsevier
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths
worldwide. Common treatment modalities for NSCLC include surgery, radiotherapy …

[HTML][HTML] Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers

TH Jones, JW Song, L Abushahin - Translational Oncology, 2022 - Elsevier
Tumor treating fields (TTFields)-an intermediate-frequency, electric field therapy-has
emerged as a promising alternative therapy for the treatment of solid cancers. Since the first …

Tumor treating fields: concept, evidence and future

M Pless, U Weinberg - Expert opinion on investigational drugs, 2011 - Taylor & Francis
Introduction: Local control is fundamental, both for the curative as well as the palliative
treatment of cancer. Tumor treating fields (TTFields) are low intensity (1–2 V/cm) …

Tumor-Treating Fields: A fourth modality in cancer treatment, new practice updates

R Arvind, SR Chandana, MJ Borad… - Critical Reviews in …, 2021 - Elsevier
Although major innovations in treatment are advancing, cancer persists as one of the
leading causes of mortality. With the rising incidence of cancer and as we treat them …

[HTML][HTML] Tumour treating fields in a combinational therapeutic approach

J Branter, S Basu, S Smith - Oncotarget, 2018 - ncbi.nlm.nih.gov
The standard of care for patients with newly diagnosed Glioblastoma multiforme (GBM) has
remained unchanged since 2005, with patients undergoing maximal surgical resection …