The introduction of more relevant cell models in early preclinical drug discovery, combined
with high-content imaging and automated analysis, is expected to increase the quality of …

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penetration of light into tissue, but many areas require improvement, especially if 3D …

The past decades have witnessed significant efforts toward the development of three-
dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D …

Most current drug screening assays used to identify new drug candidates are 2D cell-based
systems, even though such in vitro assays do not adequately re-create the in vivo complexity …

Evaluation of drug cytotoxicity traditionally relies on use of cell monolayers, which are easily
miniaturized to the 1536-well plate format. Three-dimensional (3D) cell culture models have …

Advanced three dimensional cell culture techniques have been adopted in many
laboratories to better model in vivo tissue by recapitulating multi-cellular architecture and the …

Abstract Historically, two-dimensional (2D) cell culture has been the preferred method of
producing disease models in vitro. Recently, there has been a move away from 2D culture in …

Abstract 3D organotypic culture models such as organoids and multicellular tumor spheroids
(MCTS) are becoming more widely used for drug discovery and toxicology screening. As a …

High-throughput technologies have become essential in many fields of pharmaceutical and
biological development and production. Such technologies were initially developed with …

Successful preclinical drug testing relies in part on data generated using in vitro cell culture
models that recapitulate the structure and function of tumours and other tissues in vivo. The …