Astrocytes are an abundant subgroup of cells in the central nervous system (CNS) that play
a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In …

Mood disorders have multiple phenotypes and complex underlying biological mechanisms
and, as such, there are no effective therapeutic strategies. A review of recent work on the …

Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …

Depressive disorders are widely debilitating psychiatric disease. Despite the considerable
progress in the field of depression therapy, extensive research spanning many decades has …

Data from animal models and Alzheimer's disease (AD) subjects provide clear evidence for
an activation of inflammatory pathways during the pathogenetic course of such illness …

Neurodegenerative diseases and depression are multifactorial disorders with a complex
and poorly understood physiopathology. Astrocytes play a key role in the functioning of …

Astrocytes were historically classified as supporting cells; however, it is becoming
increasingly clear that they actively contribute to neuronal functioning under normal and …

Post-stroke depression (PSD) is a frequent and disabling complication of stroke that affects
up to one-third of stroke survivors. The pathophysiology of PSD involves multiple …

Astrocytes represent a highly heterogeneous population of neural cells primarily responsible
for the homeostasis of the CNS. Astrocytes express multiple receptors for neurotransmitters …

Astrocytes are involved in various processes in the central nervous system (CNS). As the
most abundant cell type in the CNS, astrocytes play an essential role in neuronal …