One of the reasons for animals not to grow as fast as they potentially could is that fast growth
has been shown to be associated with reduced lifespan. However, we are still lacking a …

Life history has been implicated as a determinant of variation in rate of molecular evolution
amongst vertebrate species because of a negative correlation between body size and …

Many large animal species have a high risk of extinction. This is usually thought to result
simply from the way that species traits associated with vulnerability, such as low …

Telomere dysfunction limits the proliferative capacity of human cells and induces organismal
aging by activation of p53 and p21 (refs.,,,,,). Although deletion of p21 elongates the lifespan …

In 1994, two independent groups extracted DNA from several Pleistocene epoch mammoths
and noted differences among individual specimens,. Subsequently, DNA sequences have …

A common ancestor to the three p53 family members of human genes p53, p63, and p73 is
first detected in the evolution of modern‐day sea anemones, in which both structurally and …

We have identified a homolog of the mammalian p53 tumor suppressor protein in the
nematode Caenorhabditis elegans that is expressed ubiquitously in embryos. The gene …

There is a great interest in determining the impact of p53 on ageing and, for this, it is
important to discriminate among the known causes of ageing. Telomere loss is a well …

The functional capacity of a cell, tissue, organ, or organism is dependent upon its ability to
maintain the stability of its unit components. The higher the differentiated state of the system …

Mammalian lifespan differs by> 100 fold, but the mechanisms associated with such longevity
differences are not understood. Here, we conducted a study on primary skin fibroblasts …