Potential under-or overdose of antibiotics may occur in intensive care units due to high
variability in plasma concentrations. The risk is either treatment failure or toxicity. Thus …

Background: Adequate antibiotic treatment is a prerequisite for the successful treatment of
systemic infections. Based on accumulating scientific evidence, a fixed dosage regimen can …

Background and aims Intensive care antibiotic treatment faces challenges due to substantial
pharmacokinetic differences in critically ill patients. Individualized antibiotic dosing guided …

A large variation in the levels of different ß‐lactams and other antibiotics used in critically ill
patients has been documented. The aim of this study is to establish and validate a fast, ultra …

Background: Recent studies indicate that a high proportion of patients in the intensive care
unit fail to attain adequate antibiotic levels. Thus, there is a need to monitor the antibiotic …

Background: Optimization of antimicrobial therapy is a challenge in critically ill patients who
develop extreme interindividual and intraindividual pharmacokinetic variability. Therapeutic …

Empirically prescribed standard dosing regimens of antibacterial agents may result in
insufficient or excess plasma concentrations with persistently poor clinical outcomes …

Background Therapeutic drug monitoring (TDM) for antibiotic drugs represents a
consolidated practice to optimize the effectiveness and to limit the toxicity of specific drugs …

Background Recent studies show that suboptimal blood levels of β-lactam antibiotics are
present in intensive care unit (ICU) patients. A common reference method for assessing drug …

Antibiotic (ATB) prescription in an intensive care unit (ICU) requires continuous monitoring of
serum dosages due to the patient's pathophysiological condition. Dosing adjustment is …