Background: Sustained inflammation in the heart is sufficient to provoke left ventricular
dysfunction and left ventricular remodeling. Although inflammation has been linked to many …

The ubiquitin proteasome system (UPS) is critical for the regulation of many intracellular
processes necessary for cell function and survival. The absolute requirement of the UPS for …

Macroautophagy (referred to as autophagy hereafter) plays an important role in the quality
control of cellular proteins and organelles. Transcription Factor EB (TFEB) globally activates …

Proper protein degradation is required for cellular protein homeostasis and organ function.
Particularly, in post-mitotic cells, such as cardiomyocytes, unbalanced proteolysis due to …

Aims Proteasome functional insufficiency (PFI) may play an important role in the progression
of congestive heart failure but the underlying molecular mechanism is poorly understood …

In most patients with chronic heart failure (HF), levels of circulating cytokines are elevated
and the elevated cytokine levels correlate with the severity of HF and prognosis. Various …

The heart is capable of robust structural remodeling, sometimes improving performance and
sometimes leading to failure. Recent studies have uncovered a critical role for autophagy in …

The ubiquitin-proteasome system degrades most intracellular proteins, including misfolded
proteins. Proteasome functional insufficiency (PFI) has been observed in proteinopathies …

Protein quality control (PQC) senses and repairs misfolded/unfolded proteins and, if the
repair fails, degrades the terminally misfolded polypeptides through an intricate …

Increased matrix metalloprotease 9 (MMP9) after myocardial infarction (MI) exacerbates
ischemia-induced chronic heart failure (CHF). Autophagy is cardioprotective during CHF; …