The main goal of chemotherapeutic drugs is to induce massive cell death in tumors.
Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its …

With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with
major key parameters that control cancer treatment management, such as diagnosis …

Cancer cell resistance to chemotherapy is still a heavy burden that impairs treatment of
cancer patients. Both intrinsic and acquired resistance results from the numerous genetic …

Currently, acquired resistance to cisplatin (DDP) is a substantial obstacle to reducing the
morbidity and mortality due to ovarian malignant tumors. Nevertheless, cisplatin plays a vital …

Cancer still represents a major global burden, being the second leading cause of death
worldwide [1]. Standard cancer treatments include surgery, radiotherapy and chemotherapy …

Platinum-based chemotherapy, such as cisplatin, is the primary treatment for human ovarian
cancer. However, overcoming drug resistance has become an important issue in cancer …

Ovarian cancer (OC) is one of the most common gynecologic tumors worldwide and one
with the highest mortality. Cisplatin (DDP) is the first platinum-based complex approved by …

Aims Cisplatin (CDDP) is a platinum-based drug that is widely used in cancer
chemotherapy, but the development of resistance in tumor cells is a major weakness of …

Background Epithelial ovarian cancer (EOC) has a high mortality rate and is a common
malignant tumor of women, seriously impairing health. Chemoresistance is one of the major …

Transcription factor AP-1 plays a central role in HPV-mediated cervical carcinogenesis. AP-1
has also been implicated in chemo-radio-resistance but the mechanism (s) remained …