[HTML][HTML] Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer's disease-associated pathology and cognition in mice

M Wang, C Yan, X Li, T Yang, S Wu, Q Liu… - Nature …, 2024 - nature.com
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ)
clearance, which is considered as a potential therapeutic target for Alzheimer's disease …

Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage

J Rustenhoven, G Pavlou, SE Storck… - Journal of Experimental …, 2023 - rupress.org
The meningeal lymphatic network enables the drainage of cerebrospinal fluid (CSF) and
facilitates the removal of central nervous system (CNS) waste. During aging and in …

Drainage of senescent astrocytes from brain via meningeal lymphatic routes

Q Li, Y Chen, W Feng, J Cai, J Gao, F Ge… - Brain, Behavior, and …, 2022 - Elsevier
Recent progress on the central lymphatic system has greatly increased our understanding of
how the brain maintains its own waste homeostasis. Here, we showed that perivascular …

Photostimulation of cerebral and peripheral lymphatic functions

O Semyachkina‐Glushkovskaya… - Translational …, 2020 - Wiley Online Library
The recently rediscovered meningeal lymphatic system (MLS) opens new insight into
pathways of brain clearing and drainage functions that play an important role in …

[HTML][HTML] Emerging roles of meningeal lymphatic vessels in Alzheimer's disease

X Guo, G Zhang, Q Peng, L Huang… - Journal of …, 2023 - content.iospress.com
Meningeal lymphatic vessels (mLVs), the functional lymphatic system present in the
meninges, are the key drainage route responsible for the clearance of molecules, immune …

Age-associated suppression of exploratory activity during sickness is linked to meningeal lymphatic dysfunction and microglia activation

DH Goldman, T Dykstra, I Smirnov, SM Blackburn… - Nature aging, 2022 - nature.com
Peripheral inflammation triggers a transient, well-defined set of behavioral changes known
as sickness behavior,–, but the mechanisms by which inflammatory signals originating in the …

Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease

S Da Mesquita, A Louveau, A Vaccari, I Smirnov… - Nature, 2018 - nature.com
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …

[HTML][HTML] Current views on meningeal lymphatics and immunity in aging and Alzheimer's disease

S Rego, G Sanchez, S Da Mesquita - Molecular neurodegeneration, 2023 - Springer
Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …

[HTML][HTML] Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

AC Bolte, AB Dutta, ME Hurt, I Smirnov… - Nature …, 2020 - nature.com
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we
demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause …

[HTML][HTML] Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease mouse model

L Tao, Q Liu, F Zhang, Y Fu, X Zhu, X Weng… - Light: Science & …, 2021 - nature.com
Photobiomodulation, by utilizing low-power light in the visible and near-infrared spectra to
trigger biological responses in cells and tissues, has been considered as a possible …