[HTML][HTML] Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer's disease-associated pathology and cognition in mice
M Wang, C Yan, X Li, T Yang, S Wu, Q Liu… - Nature …, 2024 - nature.com
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ)
clearance, which is considered as a potential therapeutic target for Alzheimer's disease …
clearance, which is considered as a potential therapeutic target for Alzheimer's disease …
Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage
The meningeal lymphatic network enables the drainage of cerebrospinal fluid (CSF) and
facilitates the removal of central nervous system (CNS) waste. During aging and in …
facilitates the removal of central nervous system (CNS) waste. During aging and in …
Drainage of senescent astrocytes from brain via meningeal lymphatic routes
Q Li, Y Chen, W Feng, J Cai, J Gao, F Ge… - Brain, Behavior, and …, 2022 - Elsevier
Recent progress on the central lymphatic system has greatly increased our understanding of
how the brain maintains its own waste homeostasis. Here, we showed that perivascular …
how the brain maintains its own waste homeostasis. Here, we showed that perivascular …
Photostimulation of cerebral and peripheral lymphatic functions
O Semyachkina‐Glushkovskaya… - Translational …, 2020 - Wiley Online Library
The recently rediscovered meningeal lymphatic system (MLS) opens new insight into
pathways of brain clearing and drainage functions that play an important role in …
pathways of brain clearing and drainage functions that play an important role in …
[HTML][HTML] Emerging roles of meningeal lymphatic vessels in Alzheimer's disease
X Guo, G Zhang, Q Peng, L Huang… - Journal of …, 2023 - content.iospress.com
Meningeal lymphatic vessels (mLVs), the functional lymphatic system present in the
meninges, are the key drainage route responsible for the clearance of molecules, immune …
meninges, are the key drainage route responsible for the clearance of molecules, immune …
Age-associated suppression of exploratory activity during sickness is linked to meningeal lymphatic dysfunction and microglia activation
DH Goldman, T Dykstra, I Smirnov, SM Blackburn… - Nature aging, 2022 - nature.com
Peripheral inflammation triggers a transient, well-defined set of behavioral changes known
as sickness behavior,–, but the mechanisms by which inflammatory signals originating in the …
as sickness behavior,–, but the mechanisms by which inflammatory signals originating in the …
Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
[HTML][HTML] Current views on meningeal lymphatics and immunity in aging and Alzheimer's disease
S Rego, G Sanchez, S Da Mesquita - Molecular neurodegeneration, 2023 - Springer
Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …
[HTML][HTML] Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
AC Bolte, AB Dutta, ME Hurt, I Smirnov… - Nature …, 2020 - nature.com
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we
demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause …
demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause …
[HTML][HTML] Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease mouse model
L Tao, Q Liu, F Zhang, Y Fu, X Zhu, X Weng… - Light: Science & …, 2021 - nature.com
Photobiomodulation, by utilizing low-power light in the visible and near-infrared spectra to
trigger biological responses in cells and tissues, has been considered as a possible …
trigger biological responses in cells and tissues, has been considered as a possible …