Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice

ASR Sierksma, J Prickaerts, L Chouliaras… - Neurobiology of …, 2013 - Elsevier
Epidemiological evidence implies a role for chronic stress and stress-related disorders in the
etiopathogenesis of sporadic Alzheimer's disease (AD). Although chronic stress exposure …

Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model

L Hoeijmakers, SR Ruigrok, A Amelianchik… - Brain, behavior, and …, 2017 - Elsevier
Exposure to stress during the sensitive period of early-life increases the risk to develop
cognitive impairments and psychopathology later in life. In addition, early-life stress (ES) …

Effects of prenatal stress exposure on soluble Aβ and brain-derived neurotrophic factor signaling in male and female APPswe/PS1dE9 mice

ASR Sierksma, T Vanmierlo, J De Vry… - Neurochemistry …, 2012 - Elsevier
Chronic stress and stress-related disorders, such as major depression (MD), have been
shown to increase the risk for developing Alzheimer's disease (AD). Brain-derived …

Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure

MR Abbink, JM Kotah, L Hoeijmakers, A Mak… - Journal of …, 2020 - Springer
Background Early-life stress (ES) is an emerging risk factor for later life development of
Alzheimer's disease (AD). We have previously shown that ES modulates amyloid-beta …

Maternal separation exacerbates Alzheimer's disease-like behavioral and pathological changes in adult APPswe/PS1dE9 mice

J Hui, G Feng, C Zheng, H Jin, N Jia - Behavioural Brain Research, 2017 - Elsevier
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder that
gradually destroys memory and cognitive abilities in the elderly, makes a huge emotional …

Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

RP Kommaddi, A Verma, G Muniz-Terrera… - Translational …, 2023 - nature.com
Women carry a higher burden of Alzheimer's disease (AD) compared to men, which is not
accounted entirely by differences in lifespan. To identify the mechanisms underlying this …

Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice

SL Lesuis, S Weggen, S Baches, PJ Lucassen… - Translational …, 2018 - nature.com
Exposure to chronic stress or elevated glucocorticoid hormone levels in adult life has been
associated with cognitive deficits and an increased risk for Alzheimer's disease (AD). Since …

Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer's disease neuropathology in APPSwe/PS1A246E transgenic mice

X Zhang, L Li, X Zhang, W Xie, L Li, D Yang, X Heng… - Neurobiology of …, 2013 - Elsevier
Most cases of Alzheimer's disease (AD) arise through interactions between genetic and
environmental factors. It is believed that hypoxia is an important environmental factor …

[HTML][HTML] Both male and female APPswe/PSEN1dE9 mice are impaired in spatial memory and cognitive flexibility at 9 months of age

LA Hulshof, LA Frajmund, D van Nuijs… - Neurobiology of …, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia. Despite many years of
research, very limited treatment options are available. Here we aim to establish a well …

Hypothalamic-pituitary-adrenal (HPA) axis activity and anxiety-like behavior during aging: A test of the glucocorticoid cascade hypothesis in amyloidogenic APPswe …

BN Harris, BR Roberts, GM DiMarco… - General and …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive, dementing, whole-body disorder that presents
with decline in cognitive, behavioral, and emotional functions, as well as endocrine …