Background The risk of developing Alzheimer's disease (AD) is modulated by genetic and
environmental factors. Early-life stress (ELS) exposure during critical periods of brain …

In order to better understand animal models of Alzheimer's disease, novel phenotyping
strategies have been established for transgenic mouse models. In line with this, the current …

Involvement of life stress in Late-Onset Alzheimer's Disease (LOAD) has been evinced in
longitudinal cohort epidemiological studies, and endocrinologic evidence suggests …

Basic and clinical studies have reported that behavioral stress worsens the pathology of
Alzheimer disease (AD), but the underlying mechanism has not been clearly understood. In …

Amyloid-β peptide species accumulating in the brain of patients with Alzheimer's disease
are assumed to have a neurotoxic action and hence to be key actors in the physiopathology …

Transgenic mice made by crossing animals expressing mutant amyloid precursor protein
(APPswe) to mutant presenilin 1 (PS1dE9) allow for incremental increases in Aβ42 …

There is increasing evidence linking neuroinflammation to many neurological disorders
including Alzheimer's disease (AD); however, its exact contribution to disease manifestation …

Neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit
and hyperactivity disorder (ADHD) have increased over the last few decades. These …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder associated with cognitive
impairment and later dementia among the elderly. Mounting evidence shows that adverse …

Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in
permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the …