Physiologically relevant in vitro tumor models are crucial in any research setting from
preclinical drug development to functional precision oncology. Patient-derived 3D cell …

Patient-derived 3D cell culture models (PD3D®) developed as a powerful tool for disease
modelling, biomarker and drug discovery. Currently, they are gaining increasing significance …

The preclinical platform landscape in oncology has radically changed in the last 15 years,
mainly due to an increased ability to generate patient-derived models. Multiple 3D tumor cell …

Relevant in vivo and in vitro cancer models have been invaluable for our current
understanding of cancer biology, as well as for therapy development. Using appropriate …

e23538 Background: Compared to the progress in understanding and treating carcinomas
in the past decade, the options and related clinical benefit in terms of response rates and …

Patient-derived xenograft (PDX) models maintain the complex intra-tumoral biology and
heterogeneity of an intact malignancy, as well as the interplay with stromal components and …

Despite 50 years of dedicated efforts in the" War on Cancer", the results achieved in treating
cancer have been regrettably unsatisfactory. Particularly challenging are tumors …

There is cumulating evidence that in vitro 3D tumor models with increased physiological
relevance can improve the predictive value of pre‐clinical research and ultimately contribute …

We are honored to introduce a collection of five original research articles, protocols, reviews,
and perspectives on the research topic “Harnessing the Power of Patient Derived Models of …

Tumorigenic expression of programmed death-ligand 1 (PD-L1) and its receptor PD-1 is
found in many cancers, though the intrinsic roles of these proteins and how immunotherapy …