[HTML][HTML] Increased CMV IgG antibody titer is associated with non-AIDS events among virologically suppressed HIV-positive persons

AC Hodowanec, NS Lurain, S Krishnan… - Pathogens & …, 2019 - ncbi.nlm.nih.gov
Background: Among HIV-positive individuals, increased levels of inflammation and immune
activation persist even in the setting of effective antiretroviral therapy (ART) and are …

CMV co‐infection and risk of AIDS and non‐AIDS events in a large cohort of HIV‐infected patients

M Lichtner, P Cicconi, S Vita… - Journal of the …, 2012 - Wiley Online Library
In HIV‐positive patients (pts), CMV co‐infection has been proposed as a key factor in
sustaining immune activation, which in turn could play a role in determining immune …

Virologic correlates of anti-CMV IgG levels in HIV-1–Infected men

S Gianella, SR Morris, E Tatro… - The Journal of …, 2014 - academic.oup.com
In human immunodeficiency virus (HIV)–infected individuals, higher levels of anti-
cytomegalovirus (CMV) immunoglobulin G (IgG) antibody have been associated with …

Relationship between T-cell responses to CMV, markers of inflammation, and frailty in HIV-uninfected and HIV-infected men in the multicenter AIDS cohort study

JB Margolick, JH Bream, TL Nilles, H Li… - The Journal of …, 2018 - academic.oup.com
Background Both aging and treated human immunodeficiency virus (HIV)-infected
populations exhibit low-level chronic immune activation of unknown etiology, which …

Association of CMV-Specific T Cell-Mediated Immunity with CMV DNAemia and Development of CMV Disease in HIV-1–Infected Individuals

MC Aichelburg, L Weseslindtner, M Mandorfer… - PLoS …, 2015 - journals.plos.org
Background Among HIV-1–infected individuals, cytomegalovirus (CMV) reactivation and
disease occur in the setting of advanced immunosuppression. The value of a standardized …

Physical function impairment of older, HIV-infected adults is associated with cytomegalovirus immunoglobulin response

KM Erlandson, AA Allshouse, E Rapaport… - AIDS research and …, 2015 - liebertpub.com
Cytomegalovirus (CMV) is associated with poor outcomes, including physical function
impairment, in older HIV-uninfected adults. Whether CMV is associated with physical …

The Use of Humoral Responses as a Marker of CMV Burden in HIV Patients on ART Requires Consideration of T‐Cell Recovery and Persistent B‐Cell Activation

SJ Brunt, S Lee, L D'Orsogna, C Bundell… - Disease …, 2014 - Wiley Online Library
Objectives. Elevated humoral responses to cytomegalovirus (CMV) associate with increased
risk of cardiovascular disease (CVD) in HIV patients on antiretroviral therapy (ART). To …

CD8 T-cell expansion and inflammation linked to CMV coinfection in ART-treated HIV infection

ML Freeman, JC Mudd, CL Shive… - Clinical Infectious …, 2016 - academic.oup.com
Abstract Background. Persistent CD8 T-cell expansion, low CD4/CD8 T-cell ratios, and
heightened inflammation persist in antiretroviral therapy (ART)-treated human …

Asymptomatic CMV replication during early human immunodeficiency virus (HIV) infection is associated with lower CD4/CD8 ratio during HIV treatment

DM Smith, M Nakazawa, ML Freeman… - Clinical Infectious …, 2016 - academic.oup.com
Background A low CD4/CD8 ratio in human immunodeficiency virus (HIV)–infected
individuals is associated with inflammation and higher risk of non-AIDS morbidity and …

Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery

E Gomez-Mora, M Massanella, E Garcia, D Giles… - PloS one, 2017 - journals.plos.org
Some HIV-infected c-ART-suppressed individuals show incomplete CD4+ T-cell recovery,
abnormal T-cell activation and higher mortality. One potential source of immune activation …