The frequency response method, having its mathematical underpinnings in the theory of
linear dynamic systems, was utilized to rinodel pharmacokinetic systems describing the fate …

Therapeutic drug monitoring of factor VIII is well established in the treatment of patients with
hemophilia attributable to important interindividual variability. The individual initial factor VIII …

Objective: To compare the pharmacokinetic parameters after a single dose of a
monoclonally purified factor VIII concentrate in four different computer programs for …

Studies of Factor VIII pharmacokinetics in haemophiliacs can be classified into 2 groups
depending on whether single-dose or multiple-dose Factor VIII curves are used. This review …

The role of pharmacokinetic-guided dosing of factor concentrates in hemophilia is currently
a subject of debate and focuses on long-term prophylactic treatment. Few data are available …

The pharmacokinetics of Factor VIII was evaluated by mathematical modeling in a large-
scale study in 62 haemophilia-A subjects, in whom 137 plasma Factor VIII-time curves were …

A pharmacokinetic program that allows individualization of Factor VIII dosage regimens in
hemophilia patients undergoing major surgery is described. The program, which is designed …

Abstract IPA COPYRIGHT: ASHP An evaluation of 12 previously reported plasma
concentration-time curves and examination of the data from 17 hemophilia patients treated …

The pharmacokinetics of factor VIII were studied in a series of 20 hemophilia‐A patients
undergoing surgery. Regardless of the type of operation, elimination of factor VIII was shown …

An open, non‐randomized trial of continuous infusion therapy was conducted involving five
patients with severe haemophilia A who required factor VIII (FVIII) prophylaxis for elective …